CAS 2229711-68-4

ARV-471

Description:

ARV-471 is a novel investigational compound primarily being studied for its potential use in the treatment of breast cancer. It is classified as a selective estrogen receptor degrader (SERD), which means it is designed to bind to estrogen receptors and promote their degradation, thereby inhibiting estrogen-driven tumor growth. This mechanism is particularly relevant in hormone receptor-positive breast cancers, where estrogen plays a significant role in tumor proliferation. ARV-471 has shown promise in preclinical and clinical studies, demonstrating the ability to effectively reduce tumor size and improve patient outcomes. Its chemical structure features specific functional groups that enhance its binding affinity and selectivity for estrogen receptors. Additionally, ARV-471 is being evaluated for its safety profile and pharmacokinetics, which are crucial for determining its therapeutic potential. As research continues, ARV-471 may offer a new treatment option for patients with breast cancer, particularly those who have developed resistance to traditional endocrine therapies.

Formula: C₄₅H₄₉N₅O₄

Synonyms:

• 2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-, (3S)-
• 2,6-PIPERIDINEDIONE, 3-[1,3-DIHYDRO-1-OXO-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-TETRAHYDRO-6-HYDROXY-2-PHENYL
• Vepdegestrant
• ARV-471

(S)-3-(5-(4-((1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

CAS: 2229711-68-4

Formula: C₄₅H₄₉N₅O₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 723.9017

Ref: IN-DA01V7C7

ARV-471

CAS: 2229711-68-4

ARV-471

Purity: ≥95%

Molecular weight: 723.9g/mol

Ref: 54-BUP09613

ARV-471

CAS: 2229711-68-4

ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.

Formula: C₄₅H₄₉N₅O₄

Purity: 97.15% - >99.99%

Color and Shape: Solid

Molecular weight: 723.9

Ref: TM-T39710

ARV-471-d8

CAS: 2229711-68-4

Formula: C₄₅H₄₁D₈N₅O₄

Molecular weight: 731.97

Ref: 4Z-A-339003

ARV-471

CAS: 2229711-68-4

Formula: C₄₅H₄₉N₅O₄

Molecular weight: 723.92

Ref: 4Z-A-339001

ARV-471-d5

CAS: 2229711-68-4

Formula: C₄₅H₄₄D₅N₅O₄

Molecular weight: 728.95

Ref: 4Z-A-339002

ARV-471

CAS: 2229711-68-4

ARV-471 is an anticancer drug that acts as a Chinese hamster ovary (CHO) cell inhibitor. It is a potent and selective kinase inhibitor that has been shown to induce apoptosis in cancer cells. ARV-471 is a protein analog of nifedipine, which is a calcium channel blocker used to treat high blood pressure and angina. This drug works by inhibiting kinases, which are enzymes that regulate cellular growth and proliferation. ARV-471 has been demonstrated to be effective in treating various types of cancer, including breast cancer, by inhibiting the growth of tumor cells and inducing apoptosis. Its unique mechanism of action makes it a promising candidate for future cancer therapies.

Formula: C₄₅H₄₉N₅O₄

Purity: Min. 95%

Molecular weight: 723.9 g/mol

Ref: 3D-EPD71168