t-Boc-N-amido-PEG4-Val-Cit is a synthetic compound that belongs to the class of polyethylene glycol (PEG) derivatives, which are often utilized in bioconjugation and drug delivery applications. The "t-Boc" (tert-butyloxycarbonyl) group serves as a protecting group for the amine, enhancing the stability and solubility of the compound. The presence of the Val (valine) and Cit (citrulline) amino acids indicates that this compound may be involved in peptide synthesis or modification, potentially for therapeutic purposes. The PEG4 moiety contributes to increased hydrophilicity, biocompatibility, and solubility in aqueous environments, making it suitable for use in biological systems. Additionally, the structure suggests that it may be used in the development of prodrugs or targeted delivery systems, where the release of the active components can be controlled. Overall, t-Boc-N-amido-PEG4-Val-Cit is characterized by its multifunctionality, stability, and potential applications in medicinal chemistry and biopharmaceuticals.

t-Boc-N-amido-PEG4-Val-Cit

2231240-82-5: t-Boc-N-amido-PEG4-Val-Cit is a synthetic compound that belongs to the class of polyethylene glycol (PEG) derivatives, which are often utilized in bioconjugation and drug delivery applications. The "t-Boc" (tert-butyloxycarbonyl) group serves as a protecting group for the amine, enhancing the stability and solubility of the compound. The presence of the Val (valine) and Cit (citrulline) amino acids indicates that this compound may be involved in peptide synthesis or modification, potentially for therapeutic purposes. The PEG4 moiety contributes to increased hydrophilicity, biocompatibility, and solubility in aqueous environments, making it suitable for use in biological systems. Additionally, the structure suggests that it may be used in the development of prodrugs or targeted delivery systems, where the release of the active components can be controlled. Overall, t-Boc-N-amido-PEG4-Val-Cit is characterized by its multifunctionality, stability, and potential applications in medicinal chemistry and biopharmaceuticals.

<p>t-Boc-N-amido-PEG4-Val-Cit is a protease-cleavable ADC linker, featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit dipeptide. The Val-Cit dipeptide is susceptible to cleavage by cellular proteases and contains a free carboxylic acid that can couple with amines to form amides. The Boc group can be removed under acidic conditions to reveal a free primary amine, which is useful for various reactions, such as conjugation or reductive amination.</p>

CAS 2231240-82-5

t-Boc-N-amido-PEG4-Val-Cit

t-Boc-N-amido-PEG4-Val-Cit

Ref: TM-TYD-01998