CAS 22316-47-8
:Clobazam
Description:
Clobazam is a benzodiazepine derivative primarily used as an anticonvulsant and anxiolytic medication. It is characterized by its ability to enhance the effects of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor, leading to increased inhibitory neurotransmission in the central nervous system. Clobazam is typically administered orally and is known for its relatively long half-life, which allows for once-daily dosing in many cases. The substance is often prescribed for the management of seizures, particularly in patients with epilepsy, and may also be used for anxiety disorders. Its chemical structure includes a benzodiazepine ring fused to a diazepine, contributing to its pharmacological properties. Clobazam is generally well-tolerated, but like other benzodiazepines, it can lead to dependence and withdrawal symptoms if used long-term. Common side effects may include sedation, dizziness, and cognitive impairment. As with any medication, it is important for patients to use clobazam under the guidance of a healthcare professional to manage potential risks and benefits effectively.
Formula:C16H13ClN2O2
InChI:InChI=1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3
InChI key:InChIKey=CXOXHMZGEKVPMT-UHFFFAOYSA-N
SMILES:O=C1N(C=2C(N(C)C(=O)C1)=CC=C(Cl)C2)C3=CC=CC=C3
Synonyms:- 7-Chloro-1,5-dihydro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4(3H)-dione
- 7-Chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-(3H,5H)-dione
- 7-chloro-1-methyl-5-phenyl-1 H-1,5-benzodiazepine-2,4(3H,5H)-dione
- Clobazam
- Clobazepam
- Frisium
- Frizium
- H 4723
- Hr 376
- Lm 2717
- Mystan
- Nsc 336279
- Urbadan
- Urbanyl
- See more synonyms
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Found 12 products.
Clobazam
CAS:Controlled Product<p>Applications Benzodiazepine psychotherapeutic agent. Clobazam (CLB) has proven efficacy against multiple seizure types. An anxiolytic; anticonvulsant. Controlled substance (depressant).<br>References Gastaut, H., et al.: Epilepsia, 20, 437 (1979), Guberman, A., et al.: Can J. Neurol. Sci., 17, 311 (1990), Munn, R., et al.: Pediatr. Neurol. 9, 465 (1993)<br></p>Formula:C16H13ClN2O2Color and Shape:WhiteMolecular weight:300.74Clobazam
CAS:Controlled Product<p>Clobazam is an anticonvulsant drug with a broad spectrum of activity, which is used in the treatment of epilepsy. It has been shown to have a low incidence of side effects and to be well tolerated by patients in clinical trials. Clobazam is also effective against acute and chronic pain and can be used as an adjunctive therapy for the treatment of generalized anxiety disorder. This drug has been shown to bind to the α1 subunit of the GABA receptor, which may contribute to its therapeutic effect. Clobazam is metabolized by human cytochrome P450 3A4 (CYP3A4), which can lead to drug interactions if it interacts with other drugs that are metabolized by this enzyme. Clobazam binds competitively with recombinant human CYP3A4 and chemical inhibitors have also been found that bind to clobazam’s binding site on recombinant human CYP3A4.</p>Formula:C16H13ClN2O2Purity:Min. 98 Area-%Molecular weight:300.74 g/molClobazam
CAS:Controlled ProductClobazamFormula:C16H13CIN2O2Purity:100.0%Color and Shape:White SolidMolecular weight:404.00217Clobazam (1 mg/ml in Acetonitrile)
CAS:Controlled ProductFormula:C16H13ClN2O2Color and Shape:Single SolutionMolecular weight:300.74Clobazam (1 mg/ml in Methanol)
CAS:Controlled ProductFormula:C16H13ClN2O2Color and Shape:ColourlessMolecular weight:300.74Clobazam CIV
CAS:Controlled Product<p>Clobazam (inn) and methyprylon (inn)</p>Formula:C16H13ClN2O2Color and Shape:White Crystalline PowderMolecular weight:300.06656
