CAS 22348-32-9

(R)-α,α-Diphenylprolinol

Formula: C₁₇H₁₉NO

InChI: InChI=1S/C17H19NO/c19-17(16-12-7-13-18-16,14-8-3-1-4-9-14)15-10-5-2-6-11-15/h1-6,8-11,16,18-19H,7,12-13H2/t16-/m1/s1

InChI key: InChIKey=OGCGXUGBDJGFFY-MRXNPFEDSA-N

SMILES: [C@](O)([C@H]1CCCN1)(C2=CC=CC=C2)C3=CC=CC=C3

Synonyms:

• (+)-2-(Diphenylhydroxymethyl)pyrrolidine
• (+)-α,α-Diphenyl-2-pyrrolidinemethanol
• (2R)-2-[hydroxy(diphenyl)methyl]pyrrolidinium
• (2R)-α,α-Diphenyl-2-pyrrolidinemethanol
• (R)-(+)- α,α-2-pyrrolidinemethanol
• (R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine
• (R)-(+)-Alpha,Alpha-Diphenyl-2-Pyrrolidinemethanol
• (R)-(+)-Diphenyl-2-pyrrolidinemethanol
• (R)-2-(diphenylhydroxymethylpyrrolidine)
• (R)-Diphenyl(pyrrolidin-2-yl)methanol
• (R)-Diphenyl-2-pyrrolidinylmethanol
• (R)-α,α-Diphenyl-2-pyrrolidinemethanol
• (R)-α,α-Diphenylprolinol
• 2,2-diphenyl-(2R)-2-pyrrolidinemethanol
• 2-Pyrrolidinemethanol, α,α-diphenyl-, (2R)-
• 2-Pyrrolidinemethanol, α,α-diphenyl-, (R)-
• R-(+)alpha,alpha-diphenylprolinol
• R-Dpp
• alpha,alpha-Diphenyl-D-prolinol
• diphenyl[(2R)-pyrrolidin-2-yl]methanol
• α,α-Diphenyl-<span class="text-smallcaps">D</span>-prolinol

(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol

CAS: 22348-32-9

Formula: C₁₇H₁₉NO

Purity: >98.0%(GC)(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 253.35

Ref: 3B-D2365

(R)-1,1-Diphenylprolinol

CAS: 22348-32-9

Formula: C₁₇H₁₉NO

Purity: 98%

Color and Shape: Solid

Molecular weight: 253.3389

Ref: IN-DA003C50

(R)-Diphenyl(pyrrolidin-2-yl)methanol

CAS: 22348-32-9

(R)-Diphenyl(pyrrolidin-2-yl)methanol

Purity: 98%

Molecular weight: 253.34g/mol

Ref: 54-OR80131

(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol

Controlled Product

CAS: 22348-32-9

Applications (R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol is proven to have amphetamine-like effects and is being used for recreational drug use. It is one of a new class of synthetic stimulants known as pipradol derivatives. It inibits neurite growth in PC12 cells which contributes to its neurotoxic effects. It is used as a reagent in the synthesis of (S)-duloxetine which is an antidepressant drug. It is used to prepare chiral Corey-Bakshi-Shibata catalyst which is used in organic synthesis.
References Coppola, M., et al.: Toxicol. Lett., 212, 57 (2012); Lee, S., et al.: B. Kor. Chem. Soc., 35, 1894 (2014); Kaizaki, A., J. Toxicol. Sci., 35, 375 (2010); Corey, E., et al.: J. Am Chem. Soc., 109, 5551 (1987);

Formula: C₁₇H₁₉NO

Color and Shape: Neat

Molecular weight: 253.34

Ref: TR-D487380

(R)-(+)-Diphenyl-2-pyrrolidinemethanol

Controlled Product

CAS: 22348-32-9

(R)-(+)-Diphenyl-2-pyrrolidinemethanol is a chiral reagent that is used to catalyze the hydrogenolysis of esters and amides. This reaction yields a mixture of the corresponding alcohol and acid. The reagent can also be used to deprotonate azides, yielding diphenylprolinol. The product can then be hydrolyzed with an alkaline solution to form a methyl ester or an ester hydrochloride. This process is useful for the preparation of chiral alcohols and amines.

Formula: C₁₇H₁₉NO

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 253.34 g/mol

Ref: 3D-FD50554