CAS 223749-46-0

(+)-N-[2,2-Dimethyl-3(R)-hydroxy-6-(4,4,4-trifluorobutoxy)-3,4-dihydro-2H-1-benzopyran-4(S)-yl]-N-methylmethanesulfonamide

Description:

The chemical substance known as "(+)-N-[2,2-Dimethyl-3(R)-hydroxy-6-(4,4,4-trifluorobutoxy)-3,4-dihydro-2H-1-benzopyran-4(S)-yl]-N-methylmethanesulfonamide" with CAS number 223749-46-0 is a complex organic compound characterized by its unique structural features, including a benzopyran core and multiple functional groups. This compound exhibits chirality, indicated by the presence of specific stereocenters, which can influence its biological activity and interactions. The trifluorobutoxy group contributes to its lipophilicity, potentially affecting its solubility and permeability in biological systems. The methanesulfonamide moiety may enhance its pharmacological properties, making it relevant in medicinal chemistry. Additionally, the hydroxyl group can participate in hydrogen bonding, which may play a role in its reactivity and binding to biological targets. Overall, this compound's intricate structure suggests potential applications in pharmaceuticals, particularly in the development of therapeutic agents. Further studies would be necessary to fully elucidate its properties and biological effects.

Formula: C₁₇H₂₄F₃NO₅S

InChI: InChI=1S/C17H24F3NO5S/c1-16(2)15(22)14(21(3)27(4,23)24)12-10-11(6-7-13(12)26-16)25-9-5-8-17(18,19)20/h6-7,10,14-15,22H,5,8-9H2,1-4H3/t14-,15+/m0/s1

InChI key: InChIKey=SRZRLJWUQFIZRH-LSDHHAIUSA-N

SMILES: N(S(C)(=O)=O)(C)[C@H]1C=2C(OC(C)(C)[C@@H]1O)=CC=C(OCCCC(F)(F)F)C2

Synonyms:

• (+)-N-[2,2-Dimethyl-3(R)-hydroxy-6-(4,4,4-trifluorobutoxy)chroman-4(S)-yl]-N-methylmethanesulfonamide
• Hmr-1556
• Methanesulfonamide, N-[(3R,4S)-3,4-dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methyl-
• N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmethanesulfonamide
• HMR-1556 >=98% (HPLC)
• N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide

HMR 1556

Controlled Product

CAS: 223749-46-0

Formula: C₁₇H₂₄F₃NO₅S

Color and Shape: Neat

Molecular weight: 411.436

Ref: TR-H456375

N-(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl-N-methylmetanesulfonamide

CAS: 223749-46-0

N-(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl-N-methylmetanesulfonamide is a potent estrogen agonist that binds to the estrogen receptor. It has been shown to have an effect on the estrous cycle and to cause exacerbations of respiratory disease in rats. This compound also has been found to inhibit chloride transport in epithelium cells and may interact with other drug transporters. N-(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl--6-(4,4,4--trifluorobutoxy)-2H--1--benzopyran-- 4--yl--N--methylmetanesulfonamide also causes

Formula: C₁₇H₂₄F₃NO₅S

Purity: Min. 95%

Molecular weight: 411.44 g/mol

Ref: 3D-FD146183

N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide

CAS: 223749-46-0

Formula: C₁₇H₂₄F₃NO₅S

Purity: 99.90%

Molecular weight: 411.4364

Ref: IN-DA01EFWC

HMR 1556

CAS: 223749-46-0

HMR 1556 is a chromanol derivative and is an IKs blocker (IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively).

Formula: C₁₇H₂₄F₃NO₅S

Color and Shape: Solid

Molecular weight: 411.44

Ref: TM-T15487