(4E)-TCO-PEG4-amine, identified by its CAS number 2243569-24-4, is a chemical compound that features a tetracarbocyclic olefin (TCO) moiety linked to a polyethylene glycol (PEG) chain, specifically a four-unit PEG, and an amine functional group. This structure imparts several notable characteristics. The TCO component is known for its reactivity in bioorthogonal chemistry, particularly in cycloaddition reactions with strained alkynes, making it valuable for applications in bioconjugation and drug delivery. The PEG segment enhances the solubility and biocompatibility of the compound, which is crucial for pharmaceutical applications. The amine group provides sites for further functionalization, allowing for the attachment of various biomolecules or targeting ligands. Overall, (4E)-TCO-PEG4-amine is characterized by its versatility in chemical reactivity, enhanced solubility, and potential for use in innovative therapeutic strategies, particularly in the fields of medicinal chemistry and biochemistry.

TCO-PEG4-amine is a  heterobifunctional click chemistry reagent. Amine is very reactive with active NHS ester or with carboxylic acid in the presence of of activators suh as EDC. TCO moiety enable fast click chemistry with tetrazine molecule.

(4E)-TCO-PEG4-amine

2243569-24-4: (4E)-TCO-PEG4-amine, identified by its CAS number 2243569-24-4, is a chemical compound that features a tetracarbocyclic olefin (TCO) moiety linked to a polyethylene glycol (PEG) chain, specifically a four-unit PEG, and an amine functional group. This structure imparts several notable characteristics. The TCO component is known for its reactivity in bioorthogonal chemistry, particularly in cycloaddition reactions with strained alkynes, making it valuable for applications in bioconjugation and drug delivery. The PEG segment enhances the solubility and biocompatibility of the compound, which is crucial for pharmaceutical applications. The amine group provides sites for further functionalization, allowing for the attachment of various biomolecules or targeting ligands. Overall, (4E)-TCO-PEG4-amine is characterized by its versatility in chemical reactivity, enhanced solubility, and potential for use in innovative therapeutic strategies, particularly in the fields of medicinal chemistry and biochemistry.

TCO-PEG4-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.

CAS 2243569-24-4

(4E)-TCO-PEG4-amine

TCO-PEG4-amine

Ref: TM-T18772