CAS 224445-12-9

Bis(7)-tacrine

Description:

Bis(7)-tacrine, also known by its CAS number 224445-12-9, is a synthetic compound that belongs to the class of tacrine derivatives. Tacrine itself is a well-known acetylcholinesterase inhibitor, primarily studied for its potential use in treating Alzheimer's disease due to its ability to enhance cholinergic neurotransmission. Bis(7)-tacrine features a bis(tacrine) structure, which may enhance its pharmacological properties compared to its parent compound. This compound is characterized by its ability to cross the blood-brain barrier, making it a candidate for neuropharmacological applications. Its molecular structure typically includes multiple aromatic rings and nitrogen-containing functional groups, contributing to its biological activity. Research into bis(7)-tacrine focuses on its efficacy, safety, and potential side effects, as well as its mechanism of action in the central nervous system. As with many compounds in this category, understanding its pharmacokinetics and pharmacodynamics is crucial for evaluating its therapeutic potential.

Formula: C₃₃H₄₀N₄·2ClH

InChI: InChI=1S/C33H40N4.2ClH/c1(2-12-22-34-32-24-14-4-8-18-28(24)36-29-19-9-5-15-25(29)32)3-13-23-35-33-26-16-6-10-20-30(26)37-31-21-11-7-17-27(31)33;;/h4,6,8,10,14,16,18,20H,1-3,5,7,9,11-13,15,17,19,21-23H2,(H,34,36)(H,35,37);2*1H

InChI key: InChIKey=RHKXINFBJWDTSK-UHFFFAOYSA-N

SMILES: N(CCCCCCCNC1=C2C(=NC=3C1=CC=CC3)CCCC2)C4=C5C(=NC=6C4=CC=CC6)CCCC5.Cl

Synonyms:

• 1,7-Heptanediamine, N1,N7-bis(1,2,3,4-tetrahydro-9-acridinyl)-, hydrochloride (1:2)
• 1,7-Heptanediamine, N,N′-bis(1,2,3,4-tetrahydro-9-acridinyl)-, dihydrochloride
• Bis(7)-tacrine

Bis(7)-tacrine

CAS: 224445-12-9

Bis(7)-tacrine is a synthetic, dimeric acetylcholinesterase inhibitor, which is derived from the classical Alzheimer's treatment drug, tacrine. This compound functions through a dual-binding mechanism where it efficiently inhibits acetylcholinesterase by binding at two different sites, leading to increased availability of acetylcholine at synapses. Bis(7)-tacrine has been studied for its potential neuroprotective and cognitive-enhancing effects.

Formula: C₃₃H₄₂Cl₂N₄

Purity: Min. 95%

Molecular weight: 565.6 g/mol

Ref: 3D-ZIA44512

bis(7)-Tacrine

CAS: 224445-12-9

Bis(7)-tacrine dihydrochloride: dimeric AChE inhibitor; may treat Alzheimer's; blocks NMDA, antagonizes GABA A.

Formula: C₃₃H₄₂Cl₂N₄

Color and Shape: Solid

Molecular weight: 565.63

Ref: TM-T22048