The chemical substance known as 4-[[[7S)-1-[3-[[(2,2-Difluoro-1,3-benzodioxol-5-yl)methylamino]carbonyl]phenyl]-4,5,6,7-tetrahydro-3-(trifluoromethyl)-1H-indazol-7-yl]oxy]benzoic acid, with the CAS number 2244458-40-8, is a complex organic compound characterized by its intricate molecular structure. It features multiple functional groups, including a benzoic acid moiety, which contributes to its acidic properties. The presence of difluoro and trifluoromethyl groups suggests potential applications in pharmaceuticals, particularly in enhancing biological activity or modifying lipophilicity. The indazole and benzodioxole components indicate that this compound may exhibit interesting pharmacological properties, possibly acting as a bioactive agent. Its stereochemistry, indicated by the (7S) configuration, may influence its interaction with biological targets. Overall, this compound's unique structure and functional groups make it a subject of interest in medicinal chemistry and drug development, although specific biological activities and applications would require further investigation.

4-[[(7S)-1-[3-[[(2,2-Difluoro-1,3-benzodioxol-5-yl)methylamino]carbonyl]phenyl]-4,5,6,7-tetrahydro-3-(trifluoromethyl)-1H-indazol-7-yl]oxy]benzoic acid

2244458-40-8: The chemical substance known as 4-[[[7S)-1-[3-[[(2,2-Difluoro-1,3-benzodioxol-5-yl)methylamino]carbonyl]phenyl]-4,5,6,7-tetrahydro-3-(trifluoromethyl)-1H-indazol-7-yl]oxy]benzoic acid, with the CAS number 2244458-40-8, is a complex organic compound characterized by its intricate molecular structure. It features multiple functional groups, including a benzoic acid moiety, which contributes to its acidic properties. The presence of difluoro and trifluoromethyl groups suggests potential applications in pharmaceuticals, particularly in enhancing biological activity or modifying lipophilicity. The indazole and benzodioxole components indicate that this compound may exhibit interesting pharmacological properties, possibly acting as a bioactive agent. Its stereochemistry, indicated by the (7S) configuration, may influence its interaction with biological targets. Overall, this compound's unique structure and functional groups make it a subject of interest in medicinal chemistry and drug development, although specific biological activities and applications would require further investigation.

<p>ARN23765 is an F508del-CFTR corrector with an EC50 of 38 pM in human bronchial epithelial cells. It enhances the maturation and function of F508del-CFTR at the cell membrane, influencing ion transport and secretion, thereby addressing the pathological mechanisms of cystic fibrosis (CF).</p>

CAS 2244458-40-8

4-[[(7S)-1-[3-[[(2,2-Difluoro-1,3-benzodioxol-5-yl)methylamino]carbonyl]phenyl]-4,5,6,7-tetrahydro-3-(trifluoromethyl)-1H-indazol-7-yl]oxy]benzoic acid

ARN23765

Ref: TM-T205032