CAS 224452-66-8
:Retapamulin
Description:
Retapamulin is a pleuromutilin antibiotic primarily used for the treatment of skin infections caused by certain bacteria, particularly in pediatric patients. It exhibits a unique mechanism of action by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit, thereby preventing the formation of peptide bonds. This antibiotic is effective against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pyogenes. Retapamulin is typically administered topically, which minimizes systemic exposure and potential side effects. Its chemical structure features a complex bicyclic core, which is characteristic of pleuromutilins, and it is known for its stability and low propensity for resistance development. The substance is generally well-tolerated, with common side effects being localized reactions at the application site. Due to its targeted action and favorable safety profile, retapamulin represents an important option in the management of superficial skin infections.
Formula:C30H47NO4S
InChI:InChI=1S/C30H47NO4S/c1-7-28(4)16-24(35-25(33)17-36-22-14-20-8-9-21(15-22)31(20)6)29(5)18(2)10-12-30(19(3)27(28)34)13-11-23(32)26(29)30/h7,18-22,24,26-27,34H,1,8-17H2,2-6H3/t18-,19+,20-,21+,22-,24-,26+,27+,28-,29+,30+/m1/s1
InChI key:InChIKey=STZYTFJPGGDRJD-NHUWBDDWSA-N
SMILES:C[C@@H]1[C@]23[C@]([C@](C)([C@H](OC(CS[C@@H]4C[C@@]5(N(C)[C@](C4)(CC5)[H])[H])=O)C[C@](C=C)(C)[C@H]1O)[C@H](C)CC2)(C(=O)CC3)[H]
Synonyms:- Rebapamulin
- (3Ar,4R,5R,7S,8S,9R,9As,12R)-8-Hydroxy-4,7,9,12-Tetramethyl-3-Oxo-7-Vinyldecahydro-4,9A-Propanocyclopenta[8]Annulen-5-Yl 2-(((1R,3S,5S)-8-Methyl-8-Azabicyclo[3.2.1]Octan-3-Yl)Thio)Acetate
- [(1S,2R,3S,4S,6R,7R,8R,14R)-3-Hydroxy-2,4,7,14-tetramethyl-9-oxo-4-vinyltricyclo[5.4.3.01,8]tetradec-6-yl]{[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]sulfanyl}acetate
- Acetic acid, [[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
- 3a,9-propano-3aH-cyclopentacyclooctene-8-acetic acid, 6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-α-[[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-1-oxo-, ion(1-), (3aS,4R,5S,6S,8R,9R,9aR,10R)-
- SB 275833
- Retapamulin
- Acetic acid, 2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
- Mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-ylsulfanyl)acetate
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Found 9 products.
(1S,2R,3S,4S,6R,7R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxotricyclo[5.4.3.0^{1,8}]tetradecan-6-yl 2-{[(1R,3S,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]sulfanyl}acetate
CAS:Formula:C30H47NO4SPurity:97%Color and Shape:SolidMolecular weight:517.7635Retapamulin
CAS:Formula:C30H47NO4SPurity:>98.0%(HPLC)(qNMR)Color and Shape:White to Light yellow powder to crystalMolecular weight:517.77Retapamulin
CAS:<p>Retapamulin (SB-275833), a Pleuromutilin Antibacterial, binds to both E. coli and S. aureus ribosomes with similar potencies (Kd: 3 nM).</p>Formula:C30H47NO4SPurity:99.82% - 99.98%Color and Shape:SolidMolecular weight:517.76Retapamulin
CAS:Controlled Product<p>Applications Retapamulin is an antibacterial agent used as a substitute for the more commonly known Penicillin (P223505).<br>References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Dunham, J.M., et al.: Anal. Profiles Drug Subs., 1, 249 (1972),<br></p>Formula:C30H47NO4SColor and Shape:NeatMolecular weight:517.76Retapamulin
CAS:<p>Antibiotic; binds bacterial ribosomes to inhibit protein synthesis</p>Formula:C30H47NO4SPurity:Min. 95%Color and Shape:PowderMolecular weight:517.76 g/mol
![(1S,2R,3S,4S,6R,7R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxotricyclo[5.4.3.0^{1,8}]te…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA0039KJ.jpg&w=3840&q=75)
