CAS 22494-42-4

Diflunisal

Description:

Diflunisal is a non-steroidal anti-inflammatory drug (NSAID) that is primarily used for its analgesic and anti-inflammatory properties. It is characterized by its ability to inhibit the enzyme cyclooxygenase (COX), which plays a crucial role in the synthesis of prostaglandins, compounds involved in inflammation and pain signaling. Diflunisal is typically administered in the form of tablets and is known for its relatively long half-life, allowing for less frequent dosing compared to some other NSAIDs. The chemical structure of diflunisal includes a salicylic acid derivative with two fluorine atoms, which enhances its anti-inflammatory efficacy. It is often utilized in the management of conditions such as osteoarthritis and rheumatoid arthritis. While generally well-tolerated, diflunisal can cause side effects typical of NSAIDs, including gastrointestinal discomfort and potential cardiovascular risks. As with any medication, it is essential to use diflunisal under medical supervision to mitigate risks and ensure appropriate therapeutic use.

Formula: C₁₃H₈F₂O₃

InChI: InChI=1/C13H8F2O3/c14-10-3-1-8(6-11(10)15)7-2-4-12(16)9(5-7)13(17)18/h1-6,16H,(H,17,18)

InChI key: InChIKey=HUPFGZXOMWLGNK-UHFFFAOYSA-N

SMILES: FC1=C(C=CC(F)=C1)C2=CC(C(O)=O)=C(O)C=C2

Synonyms:

• 2',4'-Difluoro-4-Hydroxybiphenyl-3-Carboxylic Acid
• 2-Hydroxy-5-(2,4-difluorophenyl)benzoic acid
• 2′,4′-Difluoro-4-hydroxy[1,1′-biphenyl]-3-carboxylic acid
• 2′,4′-Difluoro-4-hydroxybiphenyl-3-carboxylic acid
• 3-Biphenylcarboxylic acid, 2',4'-difluoro-4-hydroxy-
• 3-Biphenylcarboxylic acid, 2′,4′-difluoro-4-hydroxy-
• 5-(2,4-Difluorophenyl) salicylic acid
• 5-(3,4-Difluorophenyl)-2-Hydroxy-Benzoic Acid
• Adomal
• Difludol
• Diflusinal
• Dolisal
• Doloban
• Dolobid
• Dolobis
• Flovacil
• Fluniget
• Fluodonil
• Flustar
• Mk 647
• [1,1'-Biphenyl]-3-carboxylic acid, 2',4'-difluoro-4-hydroxy-
• [1,1′-Biphenyl]-3-carboxylic acid, 2′,4′-difluoro-4-hydroxy-
• Diflunisal
• 2-(hydroxy)-5-(2,4-difluorophenyl)benzoicacid
• LABOTEST-BB LT00771921
• 1’-biphenyl]-3-carboxylicacid,2’,4’-difluoro-4-hydroxy-[
• 2',4'-Difluoro-4-hydroxy-3-biphenylcarboxylic acid
• 2',4'-DIFLUORO-4-HYDROXY[1,1'-BIPHENYL]-3-CARBOXYLIC ACID
• 2’,4’-difluoro-4-hydroxy-3-biphenylcarboxylicaci
• 1’-biphenyl)-3-carboxylicacid,2’,4’-difluoro-4-hydroxy-(
• 2’,4’-difluoro-4-hydroxy-3-biphenylcarboxylicacid
• 2',4'-DIFLUORO-4-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
• 2',4'-Difluoro-4-hydroxy-(1',1-diphenyl)-3-carboxylic acid

Diflunisal

CAS: 22494-42-4

Formula: C₁₃H₈F₂O₃

Purity: >98.0%(GC)

Color and Shape: White to Almost white powder to crystaline

Molecular weight: 250.20

Ref: 3B-D5875

Diflunisal

CAS: 22494-42-4

Color and Shape: Neat

Ref: 61-FOR3050.00

Diflunisal

CAS: 22494-42-4

Carboxylic acids with phenol function but without other

Formula: C₁₃H₈F₂O₃

Color and Shape: Powder

Molecular weight: 250.04415

Ref: 45-1197506

[1,​1'-​Biphenyl]​-​3-​carboxylic acid, 2',​4'-​difluoro-​4-​hydroxy-

CAS: 22494-42-4

Formula: C₁₃H₈F₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 250.1976

Ref: IN-DA003PIH

Diflunisal

CAS: 22494-42-4

Diflunisal (Dolobid) is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.

Formula: C₁₃H₈F₂O₃

Purity: 98.92% - 99.42%

Color and Shape: Solid

Molecular weight: 250.20

Ref: TM-T0808

Diflunisal

CAS: 22494-42-4

Formula: C₁₃H₈F₂O₃

Purity: ≥ 98%

Color and Shape: White or off-white powder

Molecular weight: 250.20

Ref: 7W-GL2053

Diflunisal

CAS: 22494-42-4

Diflunisal

Purity: ≥98%

Molecular weight: 250.2g/mol

Ref: 54-BUP15779

Diflunisal

CAS: 22494-42-4

Formula: C₁₃H₈F₂O₃

Color and Shape: White To Off-White Solid

Molecular weight: 250.20

Ref: 4Z-D-523

Diflunisal

CAS: 22494-42-4

Formula: C₁₃H₈F₂O₃

Color and Shape: Neat

Molecular weight: 250.20

Ref: 04-C12631600

Diflunisal

CAS: 22494-42-4

Formula: C₁₃H₈F₂O₃

Color and Shape: White Solid

Molecular weight: 250.20

Ref: 86-MM3050.00

2',4'-Difluoro-4-hydroxy[1,1'-biphenyl]-3-carboxylic acid

CAS: 22494-42-4

2',4'-Difluoro-4-hydroxy[1,1'-biphenyl]-3-carboxylic acid

Formula: C₁₃H₈F₂O₃

Purity: 98%

Color and Shape: pale yellow solid

Molecular weight: 250.20g/mol

Ref: 54-PC11123

Diflunisal

CAS: 22494-42-4

Formula: C₁₃H₈F₂O₃

Molecular weight: 250.20

Ref: ST-EA-CP-D50000

Diflunisal

Controlled Product

CAS: 22494-42-4

Applications Diflunisal acts as an analgesic agent, used in Alzheimer’s studies (1,2,3) as an anti-inflammatory. As well as in autolytic regulation of human kallikrein -related peptidase 6 (4).
References 1. Little, S. et al.: J Biol Chem. 1997 Oct 3;272(40):25135-42.2. Diamandis, E. et al.: Clin. Biochem. 2000 Jul;33(5):369-75.3. Hutchinson, S. et al.: Clin. Chem. 2003 May;49(5):746-51. 4. Baber, S et al.: Biochemistry. 2007 May 1;46(17):5209-17.

Formula: C₁₃H₈F₂O₃

Color and Shape: Neat

Molecular weight: 250.20

Ref: TR-D445751

Diflunisal-d3

Controlled Product

CAS: 22494-42-4

Applications Labelled Diflunisal. Analgesic; anti-inflammatory.
References Little, S., et al.: J. Biol. Chem., 272, 25135 (1997), Diamandis, E., et al.: Clin. Biochem., 33, 369 (2000), Hutchinson, S., et al.: Clin. Chem., 49, 746 (2003), Blaber, S., et al.: Biochemistry, 46, 5209 (2007),

Formula: C₁₃D₃H₅F₂O₃

Color and Shape: Neat

Molecular weight: 253.216

Ref: TR-D445752

Diflunisal

CAS: 22494-42-4

Diflunisal is a nonsteroidal anti-inflammatory drug (NSAID), which is a synthetic derivative of salicylic acid. It is primarily sourced through chemical synthesis rather than extraction from natural elements. Diflunisal functions by inhibiting the cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, which play a crucial role in the biosynthesis of prostaglandins. This inhibition results in reduced production of prostaglandins, compounds involved in inflammation and pain signaling pathways.

Formula: C₁₃H₈F₂O₃

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 250.2 g/mol

Ref: 3D-FD16025

2′,4′-Difluoro-4-hydroxy-biphenyl-3-carboxylic acid

CAS: 22494-42-4

Formula: C₁₃H₈F₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 250.201

Ref: 10-F031599