CAS 224946-77-4

2-Amino-7-(2-deoxy-β-D-erythro-pentofuranosyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

Description:

2-Amino-7-(2-deoxy-β-D-erythro-pentofuranosyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, with CAS number 224946-77-4, is a nucleoside analog that exhibits structural features characteristic of both pyrimidine and purine derivatives. This compound contains a pyrrolo[3,2-d]pyrimidine core, which contributes to its potential biological activity, particularly in the context of antiviral and anticancer research. The presence of the 2-deoxy-β-D-erythro-pentofuranosyl moiety suggests that it may mimic natural nucleosides, allowing it to interact with nucleic acid synthesis pathways. Its amino group at the 2-position and the carbonyl group at the 4-position are critical for its reactivity and biological interactions. The compound's solubility, stability, and reactivity can vary based on environmental conditions such as pH and temperature, which are important for its application in biochemical assays or therapeutic contexts. Overall, this compound represents a significant interest in medicinal chemistry due to its potential roles in inhibiting nucleic acid synthesis and modulating biological processes.

Formula: C₁₁H₁₄N₄O₄

InChI: InChI=1S/C11H14N4O4/c12-11-14-8-4(2-13-9(8)10(18)15-11)6-1-5(17)7(3-16)19-6/h2,5-7,13,16-17H,1,3H2,(H3,12,14,15,18)/t5-,6+,7+/m0/s1

InChI key: InChIKey=COOZQOORGUKSMK-RRKCRQDMSA-N

SMILES: O=C1C2=C(C(=CN2)[C@@H]3O[C@H](CO)[C@@H](O)C3)NC(N)=N1

Synonyms:

• 2-Amino-7-(2-deoxy-β-D-erythro-pentofuranosyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
• 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-7-(2-deoxy-β-D-erythro-pentofuranosyl)-1,5-dihydro-
• 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-7-(2-deoxy-β-D-erythro-pentofuranosyl)-3,5-dihydro-

9-Deaza-2'-deoxyguanosine

CAS: 224946-77-4

9-Deaza-2'-deoxyguanosine is a novel synthetic nucleoside that activates the ribonucleotide reductase enzyme. The activation of this enzyme was found to be dependent on the presence of diphosphate, which is a cofactor for this enzyme. 9-Deaza-2'-deoxyguanosine has been shown to inhibit the growth of cells in culture and to induce apoptosis. It also inhibits viral replication by interfering with the synthesis of viral DNA. In addition, 9-Deaza-2'-deoxyguanosine can inhibit tumor cell proliferation and promote differentiation in vitro.

Formula: C₁₁H₁₄N₄O₄

Purity: Min. 95%

Molecular weight: 266.25 g/mol

Ref: 3D-ZIA94677