CAS 225101-69-9

L-Alanine-2,3,3,3-d4,N-[(9H-fluoren-9-ylmethoxy)carbonyl]- (9CI)

Description:

L-Alanine-2,3,3,3-d4,N-[(9H-fluoren-9-ylmethoxy)carbonyl]- (9CI) is a deuterated derivative of the amino acid L-alanine, which is commonly used in biochemical research and synthesis. The presence of deuterium (d4) indicates that four hydrogen atoms in the molecule are replaced with deuterium, a stable isotope of hydrogen, which can be useful in NMR spectroscopy and other analytical techniques. The N-[(9H-fluoren-9-ylmethoxy)carbonyl] group serves as a protective group for the amino functionality, facilitating the synthesis of peptides and other derivatives while preventing unwanted reactions. This compound is typically white to off-white in appearance and is soluble in polar solvents such as water and methanol. Its molecular structure allows for specific interactions in biological systems, making it valuable in studies involving protein synthesis and metabolic pathways. As with many chemical substances, proper handling and storage are essential to maintain its stability and integrity for research applications.

Formula: C₁₈H₁₃D₄NO₄

Fmoc-[D₄]Ala-OH

CAS: 225101-69-9

Fmoc-(D₄)-Ala-OH was used by Bowman and Zaia in the SPPS of peptide tags for the stable isotopic labeling of carbohydrates which allowed their mass spectroscopic quantification. For ²H-NMR-studies on the influence of Pro on the folding of WALP transmembrane peptides, Koeppe’s group incorporated pairs of deuterated alanines by introducing Fmoc-(D₄)-Ala-OH (60-100%) at selected sequence positions.

Formula: C₁₈H₁₃D₄NO₄

Purity: > 95%

Molecular weight: 315.37

Ref: 01-4071077

Fmoc-Ala-OH (2,3,3,3-D4)

CAS: 225101-69-9

Formula: C₁₈H₁₃D₄NO₄

Molecular weight: 315.36

Ref: 7W-GM8393

L-Alanine-2,3,3,3-d4-N-FMOC

CAS: 225101-69-9

Formula: CD₃CD(NHFMOC)COOH

Purity: 98 atom % D

Color and Shape: White Solid

Molecular weight: 315.36

Ref: 3U-D5723

N-Fmoc-L-alanine-d4

Controlled Product

CAS: 225101-69-9

Applications N-Fmoc-L-alanine-d4 is the isotope labelled analog of N-Fmoc-L-alanine (F619945); the Fmoc-protected form of L-Alanine (A481500). L-Alanine is used to make in-vivo measurement of glucose and alanine metabolism in studies of patients with diabetes. L-Alanine is a non-essential amino acid for human development and is one of the 20 amino acids encoded by the genetic code.
References Bier, D.M. et al.: Diabetes, 26, 1005 (1977); Capaldo, B. et al.: J. Clin. Endocrinol. Metab., 71, 1220 (1990); Giacca, A. et al.: Diabetes, 47, 1763 (1998)

Formula: C₁₈D₄H₁₃NO₄

Color and Shape: Neat

Molecular weight: 315.36

Ref: TR-F619947

Fmoc-[D4]Ala-OH

Controlled Product

CAS: 225101-69-9

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Formula: C₁₈H₁₃D₄NO₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 315.35 g/mol

Ref: 3D-FF111394