CAS 2252-51-9

2-Chloro-4-fluorobenzoic acid

Description:

2-Chloro-4-fluorobenzoic acid is an aromatic carboxylic acid characterized by the presence of both chlorine and fluorine substituents on the benzene ring. Specifically, the chlorine atom is located at the second position and the fluorine atom at the fourth position relative to the carboxylic acid group. This compound typically appears as a white to off-white crystalline solid and is soluble in organic solvents, with limited solubility in water. It exhibits acidic properties due to the carboxylic acid functional group, allowing it to participate in various chemical reactions, such as esterification and amidation. The presence of halogen substituents can influence its reactivity and biological activity, making it of interest in pharmaceutical and agrochemical research. Additionally, 2-chloro-4-fluorobenzoic acid can serve as an intermediate in the synthesis of more complex organic compounds. Safety data indicates that, like many halogenated compounds, it should be handled with care due to potential toxicity and environmental impact.

Formula: C₇H₄ClFO₂

InChI: InChI=1S/C7H4ClFO2/c8-6-3-4(9)1-2-5(6)7(10)11/h1-3H,(H,10,11)

InChI key: InChIKey=GRPWQLDSGNZEQE-UHFFFAOYSA-N

SMILES: C(O)(=O)C1=C(Cl)C=C(F)C=C1

Synonyms:

• 1-Chloro-2-Fluorobezene
• 2-Chloro-4-Fluorobenzoate
• 2-Chloro-4-Fluorobenzoic
• 2-Chloro-4-fluorobenzoic acid 99%
• 2-Chloro-4-fluorobenzoicacid99%
• 2-[4-(Trifluoromethyl)Phenyl]Propan-2-Ol
• Benzoic acid, 2-chloro-4-fluoro-
• Rarechem Al Bo 0405
• Timtec-Bb Sbb003795
• 2-Chloro-4-fluorobenzoic acid
• 2-chloro-4-fiuorobenzoic acid

2-Chloro-4-fluorobenzoic Acid

CAS: 2252-51-9

Formula: C₇H₄ClFO₂

Purity: >98.0%(GC)(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 174.56

Ref: 3B-C1350

2-Chloro-4-fluorobenzoic acid, 98%

CAS: 2252-51-9

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₇H₄ClFO₂

Purity: 98%

Color and Shape: White to pale cream, Crystals or powder or crystalline powder

Molecular weight: 174.56

Ref: 02-A14953

2-Chloro-4-fluorobenzoic acid

CAS: 2252-51-9

Formula: C₇H₄ClFO₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 174.5569

Ref: IN-DA00337V

2-Chloro-4-fluorobenzoic acid

CAS: 2252-51-9

2-Chloro-4-fluorobenzoic acid

Formula: C₇H₄ClFO₂

Purity: 97%

Color and Shape: white with black solids powder

Molecular weight: 174.56g/mol

Ref: 54-PC1860L

2-Chloro-4-fluorobenzoic acid

CAS: 2252-51-9

Purity: >95%

Molecular weight: 174.56

Ref: FT-C14498

2-Chloro-4-fluorobenzoic acid

CAS: 2252-51-9

Formula: C₇H₄ClFO₂

Purity: ≥ 98.0%

Color and Shape: Off-white or light-yellow powder

Molecular weight: 174.56

Ref: 7W-GK8367

2-Chloro-4-fluorobenzoic acid

CAS: 2252-51-9

Formula: C₇H₄ClFO₂

Purity: 97%

Color and Shape: Off-white powder

Molecular weight: 174.56

Ref: 10-F004428

2-Chloro-4-Fluorobenzoic Acid pure, 98%

CAS: 2252-51-9

Formula: C₇H₄ClFO₂

Purity: min. 98%

Color and Shape: White to off-white, Crystalline powder, Clear

Molecular weight: 174.56

Ref: SR-17703

2-Chloro-4-fluorobenzoic Acid

Controlled Product

CAS: 2252-51-9

Applications 2-Chloro-4-fluorobenzoic Acid s a useful synthetic intermediate. It can be used to prepare aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists. It can also be used to synthesize (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as arginine vasopressin V2 receptor agonists.
References Barnett, H., et al.: Bioorg. Med. Chem. Lett., 19, 158 (2009); Tsukamoto, I., et al.: Bioog. Med. Chem., 16, 9524 (2008)

Formula: C₇H₄ClFO₂

Color and Shape: Neat

Molecular weight: 174.56

Ref: TR-C364835