Osimertinib-13CD3, identified by the CAS number 2254100-49-5, is a labeled derivative of osimertinib, a targeted therapy primarily used in the treatment of non-small cell lung cancer (NSCLC) with specific mutations in the epidermal growth factor receptor (EGFR). This compound features a deuterated form, indicated by the "13CD3" label, which signifies the presence of deuterium, a stable isotope of hydrogen. The incorporation of deuterium can enhance the pharmacokinetic properties of the drug, potentially improving its metabolic stability and reducing the rate of clearance from the body. Osimertinib itself functions as a selective inhibitor of mutant EGFR, particularly the T790M mutation, and is known for its ability to penetrate the blood-brain barrier, making it effective against brain metastases. The characteristics of Osimertinib-13CD3, including its molecular structure, solubility, and stability, are essential for research and development purposes, particularly in pharmacological studies and clinical applications.

Osimertinib-13CD3

2254100-49-5: Osimertinib-13CD3, identified by the CAS number 2254100-49-5, is a labeled derivative of osimertinib, a targeted therapy primarily used in the treatment of non-small cell lung cancer (NSCLC) with specific mutations in the epidermal growth factor receptor (EGFR). This compound features a deuterated form, indicated by the "13CD3" label, which signifies the presence of deuterium, a stable isotope of hydrogen. The incorporation of deuterium can enhance the pharmacokinetic properties of the drug, potentially improving its metabolic stability and reducing the rate of clearance from the body. Osimertinib itself functions as a selective inhibitor of mutant EGFR, particularly the T790M mutation, and is known for its ability to penetrate the blood-brain barrier, making it effective against brain metastases. The characteristics of Osimertinib-13CD3, including its molecular structure, solubility, and stability, are essential for research and development purposes, particularly in pharmacological studies and clinical applications.

Osimertinib-13C-d3, N-13CD3 (AZD9291-13C-d3, N-13CD3)

<p>Applications Osimertinib 13CD3 is an isotope labelled compound of Osimertinib (A808075). Osimertinib is a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).<br>References Finlay, M.R.V., et al.: J. Med. Chem., 57, 8249 (2014);<br></p>

CAS 2254100-49-5

Osimertinib-13CD3

Osimertinib-13C-d3, N-13CD3 (AZD9291-13C-d3, N-13CD3)

Ref: 4Z-A-194065

Osimertinib-13CD3

Ref: TR-O702277