CAS 22568-64-5

Diacetolol

Description:

Diacetolol, with the CAS number 22568-64-5, is a chemical compound that belongs to the class of beta-blockers, which are primarily used in the treatment of cardiovascular conditions. It is characterized by its ability to selectively block beta-adrenergic receptors, leading to a decrease in heart rate and blood pressure. Diacetolol is known for its relatively high lipid solubility, which can influence its pharmacokinetics and distribution within the body. The compound typically exhibits moderate oral bioavailability and is metabolized in the liver, with its metabolites being excreted primarily through the urine. In terms of physical properties, diacetolol is usually presented as a white to off-white crystalline powder, and it is soluble in organic solvents while having limited solubility in water. Its therapeutic applications extend beyond hypertension, as it may also be utilized in managing conditions such as anxiety and certain types of arrhythmias. As with any medication, potential side effects and contraindications should be considered when prescribing diacetolol.

Formula: C₁₆H₂₄N₂O₄

InChI: InChI=1S/C16H24N2O4/c1-10(2)17-8-14(21)9-22-16-6-5-13(18-12(4)20)7-15(16)11(3)19/h5-7,10,14,17,21H,8-9H2,1-4H3,(H,18,20)

InChI key: InChIKey=AWOGXJOBNAWQSF-UHFFFAOYSA-N

SMILES: O(CC(CNC(C)C)O)C1=C(C(C)=O)C=C(NC(C)=O)C=C1

Synonyms:

• (1)-N-(3-Acetyl-4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)acetamide
• (RS)-1-(2-Acetyl-4-acetamidophenoxy)-2-hydroxy-3-isopropylaminopropane
• 1-(4-Acetamido-2-acetylphenoxy)-2-hydroxy-3-isopropylaminopropane
• <span class="text-smallcaps">DL</span>-1-(2-Acetyl-4-acetamidophenoxy)-2-hydroxy-3-isopropylaminopropane
• Acetamide, N-(3-acetyl-4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)-, (+-)-
• Acetanilide, 3'-acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)-, DL- (8CI)
• Acetanilide, 3′-acetyl-4′-[2-hydroxy-3-(isopropylamino)propoxy]-, <span class="text-smallcaps">DL</span>-
• Acetylacebutolol
• Brn 2156350
• DL-1-(2-Acetyl-4-acetamidophenoxy)-2-hydroxy-3-isopropylaminopropane
• Diacetol
• Diacetolol
• Diacetolol [INN:BAN]
• Diacetololum
• Diacetololum [INN-Latin]
• M and B 16942
• N-{3-acetyl-4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide
• Unii-4Er0Cz5G7C
• N-[3-Acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]acetamide

ACEBUTOLOL IMPURITY B CRS

CAS: 22568-64-5

ACEBUTOLOL IMPURITY B CRS

Ref: 41-Y0000359

Acebutolol Related Compound B (N-{3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}acetamide)

CAS: 22568-64-5

Compounds containing a pyrimidine ring (whether or not

Formula: C₁₆H₂₄N₂O₄

Color and Shape: Powder

Molecular weight: 308.17361

Ref: 45-1000623

Diacetolol

CAS: 22568-64-5

Diacetolol

Purity: ≥95%

Molecular weight: 308.38g/mol

Ref: 54-OR1006311

Diacetolol

CAS: 22568-64-5

Diacetolol is the major metabolite of acebutolol, a selective beta blockers used to treat hypertension, angina pectoris and arrhythmia.

Formula: C₁₆H₂₄N₂O₄

Color and Shape: Solid

Molecular weight: 308.37

Ref: TM-T21010

Acebutolol EP Impurity B HCl

CAS: 22568-64-5

Formula: C₁₆H₂₄N₂O₄·HCl

Molecular weight: 308.38 36.46

Ref: 4Z-A-169004

rac Diacetolol

Controlled Product

CAS: 22568-64-5

Impurity Acebutolol EP Impurity B/ Acebutolol USP RC B
Applications The principal metabolite of Acebutolol (A123800) with less β-adrenoceptor blocking potency but greater cardioselectivity (atrial relative to tracheal tissue. Acebutolol EP Impurity B.
References Basil, B. et al.: Nouv. Pres, Med., 7, 3258 (1978); Choi, S. et al.: Arch. Pharm. Res., 25, 541 (2002); Basil, B. et al.: Eur. J. Pharmacol., 80, 47 (1982);

Formula: C₁₆H₂₄N₂O₄

Color and Shape: Neat

Molecular weight: 308.37

Ref: TR-D305200

rac-Diacetolol

CAS: 22568-64-5

Rac-Diacetolol is a racemic mixture of two isomers, (+) and (-), of acebutolol. Rac-Diacetolol is used to treat bowel disease, chronic oral inflammation and cardiac arrhythmias. It is also used as an experimental solubility probe in the study of the interactions between drugs and biological membranes. Rac-Diacetolol has been shown to have a low affinity for cytochrome P450 enzymes, which are responsible for metabolizing many drugs in the body. Rac-Diacetolol has been found to reduce plasma concentrations of PCSK9 antibody in patients with inflammatory bowel disease. The drug also has anti-inflammatory properties that may be due to its inhibition of prostaglandin synthesis.

Formula: C₁₆H₂₄N₂O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 308.37 g/mol

Ref: 3D-ID27503

Diacetolol

CAS: 22568-64-5

Purity: 96%

Molecular weight: 308.3779907

Ref: 10-F601069

Acebutolol EP Impurity B

CAS: 22568-64-5

Formula: C₁₆H₂₄N₂O₄

Molecular weight: 308.38

Ref: ST-EA-CP-A94002