CAS 2259-96-3

Cyclothiazide

Description:

Cyclothiazide is a thiazide derivative primarily recognized for its diuretic properties, which are utilized in the management of hypertension and edema. It functions by inhibiting sodium reabsorption in the distal convoluted tubule of the nephron, leading to increased excretion of sodium and water. This compound is characterized by its unique bicyclic structure that incorporates a thiazide ring, contributing to its pharmacological activity. Cyclothiazide is typically administered orally and exhibits a moderate onset of action, with effects lasting several hours. Its solubility in water is limited, which can influence its bioavailability and therapeutic efficacy. Additionally, cyclothiazide may have interactions with other medications and can lead to electrolyte imbalances, necessitating monitoring of serum electrolytes during treatment. As with many thiazide diuretics, potential side effects include dehydration, hypotension, and metabolic changes. Overall, cyclothiazide serves as an important agent in the therapeutic arsenal for managing fluid retention and high blood pressure, although its use must be carefully managed to mitigate adverse effects.

Formula: C₁₄H₁₆ClN₃O₄S₂

InChI: InChI=1S/C14H16ClN3O4S2/c15-10-5-11-13(6-12(10)23(16,19)20)24(21,22)18-14(17-11)9-4-7-1-2-8(9)3-7/h1-2,5-9,14,17-18H,3-4H2,(H2,16,19,20)

InChI key: InChIKey=BOCUKUHCLICSIY-UHFFFAOYSA-N

SMILES: O=S1(=O)NC(C2C3CC(C2)C=C3)NC=4C1=CC(S(N)(=O)=O)=C(Cl)C4

Synonyms:

• 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-, 1,1-dioxide
• 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-(5-norbornen-2-yl)-, 1,1-dioxide
• 3-[(1S,4S)-bicyclo[2.2.1]hept-5-en-2-yl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• 6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide
• 6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
• 6-Chloro-3-(5-bicyclo[2.2.1]hept-2-enyl)-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
• 6-Chloro-3-(5-norbornen-2-yl)-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide
• 6-chloro-3,4-dihydro-3-(8,9,10-trinorborn-5-en-2-yl)-2H-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide
• Anhydron
• Aquirel
• Ciclotiazida
• Cyclothiazid
• Doburil
• Fluidil
• Lilly 35483
• MDi 193
• Renazide

2H-1,2,4-Benzothiadiazine-7-sulfonamide,3-bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-, 1,1-dioxide

CAS: 2259-96-3

Formula: C₁₄H₁₆ClN₃O₄S₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 389.8775

Ref: IN-DA00IMF7

6-Chloro-3,4-Dihydro-3-(2-Norbornen-5-Yl)-2H-1,2-4-Benzothiadiazine-7-Sulfonamide 1,1-Dioxide

CAS: 2259-96-3

6-Chloro-3,4-Dihydro-3-(2-Norbornen-5-Yl)-2H-1,2-4-Benzothiadiazine-7-Sulfonamide 1,1-Dioxide

Purity: 98%

Molecular weight: 389.88g/mol

Ref: 54-OR1012005

Cyclothiazide

CAS: 2259-96-3

Cyclothiazide

Purity: ≥98%

Molecular weight: 389.88g/mol

Ref: 54-BUP10354

Cyclothiazide

CAS: 2259-96-3

Formula: C₁₄H₁₆ClN₃O₄S₂

Purity: ≥ 95.0%

Color and Shape: White to off-white or light yellow powder

Molecular weight: 389.88

Ref: 7W-GP0568

Cyclothiazide (mixture of isomers)

CAS: 2259-96-3

Formula: C₁₄H₁₆ClN₃O₄S₂

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 389.87

Ref: 3B-C3392

Cyclothiazide

CAS: 2259-96-3

Color and Shape: Neat

Ref: 04-C11836600

Cyclothiazide

Controlled Product

CAS: 2259-96-3

Formula: C₁₄H₁₆ClN₃O₄S₂

Color and Shape: Neat

Molecular weight: 389.88

Ref: 86-MM3047.00

Cyclothiazide

CAS: 2259-96-3

Cyclothiazide enhances AMPA receptors, prevents desensitization, and boosts glutamic acid response (EC50 = 3.8µM).

Formula: C₁₄H₁₆ClN₃O₄S₂

Purity: 98.23% - 99.49%

Color and Shape: Crystals From Dilute Alcohol Solid

Molecular weight: 389.88

Ref: TM-T4573

Cyclothiazide

Controlled Product

CAS: 2259-96-3

Applications Diuretic; antihypertensive. A subunit-specific inhibitor of GABAC receptors.
References Wentling, C.D., et al.: Anal. Profiles Drug Subs., 1, 65 (1972), Dingledine, R., et al.: Pharmacol. Rev., 51, 7 (1999), Qian, H., et al.: J. Neurobiol., 40, 67 (1999), Qian, H., et al.: Mol. Pharmacol., 67, 470 (2005), Hadley, S., et al.: J. Physiol., 581, 1001 ( 2007),

Formula: C₁₄H₁₆ClN₃O₄S₂

Color and Shape: White To Grey

Molecular weight: 389.88

Ref: TR-C988960

Cyclothiazide

CAS: 2259-96-3

M01473 - Cyclothiazide

Formula: C₁₄H₁₆ClN₃O₄S₂

Purity: >98%

Color and Shape: Solid

Molecular weight: 389.8699951171875

Ref: 10-M01473

Cyclothiazide (AS) (DISCONTINUED)

CAS: 2259-96-3

Sulfonamides used as drugs

Formula: C₁₄H₁₆ClN₃O₄S₂

Color and Shape: White Off-White Powder

Molecular weight: 389.88

Ref: 45-1159008

Cyclothiazide

CAS: 2259-96-3

Color and Shape: Neat

Ref: 61-FOR3047.00