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CAS 2259-96-3

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Cyclothiazide

Description:
Cyclothiazide is a thiazide derivative primarily recognized for its diuretic properties, which are utilized in the management of hypertension and edema. It functions by inhibiting sodium reabsorption in the distal convoluted tubule of the nephron, leading to increased excretion of sodium and water. This compound is characterized by its unique bicyclic structure that incorporates a thiazide ring, contributing to its pharmacological activity. Cyclothiazide is typically administered orally and exhibits a moderate onset of action, with effects lasting several hours. Its solubility in water is limited, which can influence its bioavailability and therapeutic efficacy. Additionally, cyclothiazide may have interactions with other medications and can lead to electrolyte imbalances, necessitating monitoring of serum electrolytes during treatment. As with many thiazide diuretics, potential side effects include dehydration, hypotension, and metabolic changes. Overall, cyclothiazide serves as an important agent in the therapeutic arsenal for managing fluid retention and high blood pressure, although its use must be carefully managed to mitigate adverse effects.
Formula:C14H16ClN3O4S2
InChI:InChI=1S/C14H16ClN3O4S2/c15-10-5-11-13(6-12(10)23(16,19)20)24(21,22)18-14(17-11)9-4-7-1-2-8(9)3-7/h1-2,5-9,14,17-18H,3-4H2,(H2,16,19,20)
InChI key:InChIKey=BOCUKUHCLICSIY-UHFFFAOYSA-N
SMILES:O=S1(=O)NC(C2C3CC(C2)C=C3)NC=4C1=CC(S(N)(=O)=O)=C(Cl)C4
Synonyms:
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-, 1,1-dioxide
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-(5-norbornen-2-yl)-, 1,1-dioxide
  • 3-[(1S,4S)-bicyclo[2.2.1]hept-5-en-2-yl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • 6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide
  • 6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
  • 6-Chloro-3-(5-bicyclo[2.2.1]hept-2-enyl)-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
  • 6-Chloro-3-(5-norbornen-2-yl)-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide
  • 6-chloro-3,4-dihydro-3-(8,9,10-trinorborn-5-en-2-yl)-2H-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide
  • Anhydron
  • Aquirel
  • See more synonyms
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