CAS 22601-59-8

Bacitracin F, 1-[N-[[2-(1-amino-2-methylbutyl)-4,5-dihydro-4-thiazolyl]carbonyl]-l-leucine]-

Description:

Bacitracin F is a polypeptide antibiotic that is primarily derived from the bacterium Bacillus subtilis. It is known for its effectiveness against a variety of Gram-positive bacteria, making it valuable in both clinical and agricultural applications. The chemical structure of Bacitracin F includes a complex arrangement of amino acids, which contributes to its antibacterial properties. It functions by inhibiting bacterial cell wall synthesis, thereby preventing the growth and reproduction of bacteria. Bacitracin F is typically used topically due to its potential toxicity when administered systemically. Its solubility in water is limited, which can affect its formulation in pharmaceutical products. Additionally, it is important to note that Bacitracin F may cause allergic reactions in some individuals, and its use is often restricted to specific conditions. As with many antibiotics, the emergence of resistance is a concern, necessitating careful consideration of its application in both medical and agricultural settings.

Formula: C₆₆H₁₀₃N₁₇O₁₆S

InChI: InChI=1/C66H103N17O16S/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,72)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)

SMILES: CCC(C)C(C1=NC(CS1)C(=NC(CC(C)C)C(=NC(CCC(=O)O)C(=NC(C(C)CC)C(=NC1CCCCN=C(C(CC(=N)O)N=C(C(CC(=O)O)N=C(C(Cc2cnc[nH]2)N=C(C(Cc2ccccc2)N=C(C(C(C)CC)N=C(C(CCCN)N=C1O)O)O)O)O)O)O)O)O)O)O)N

Synonyms:

• Bacitracin A
• Baciguent
• Bacitracin A2a
• Nsc 45737
• Solu-Tracin 50
• Unii-Dda3Rrx0P7

Bacitracin A-d7 Tritrifluoroacetate

CAS: 22601-59-8

Formula: C₆₆H₉₆D₇N₁₇O₁₆S·3C₂HF₃O₂

Molecular weight: 1429.76 3*114.02

Ref: 4Z-PB-073036

Bacitracin A

CAS: 22601-59-8

Formula: C₆₆H₁₀₃N₁₇O₁₆S

Color and Shape: White To Off-White Solid

Molecular weight: 1422.71

Ref: 4Z-PB-073003

Bacitracin A (Technical Grade)

CAS: 22601-59-8

Applications Bacitracin A is a peptide antibiotic.
References Eppelmann, K., et al.: J. Biol. Chem., 276, 34824 (2001); Mei, L., et al.: Biomat., 34, 10328 (2013);

Formula: C₆₆H₁₀₃N₁₇O₁₆S

Color and Shape: White To Light Yellow

Molecular weight: 1422.69

Ref: TR-B106533

Bacitracin A

CAS: 22601-59-8

Bacitracin A is an antibiotic peptide, which is isolated from the bacterium Bacillus subtilis. It functions by interfering with the cell wall synthesis of bacteria. Specifically, Bacitracin A inhibits the dephosphorylation of the C55-isoprenyl pyrophosphate molecule, an essential lipid carrier that transports peptidoglycan building blocks to the growing cell wall. This disruption leads to the inhibition of peptidoglycan synthesis, a critical component of bacterial cell walls, resulting in cell lysis and death.

Formula: C₆₆H₁₀₃N₁₇O₁₆S

Purity: Min. 95%

Molecular weight: 1,422.7 g/mol

Ref: 3D-XAA60159

Bacitracin A

CAS: 22601-59-8

Formula: C₆₆H₁₀₃N₁₇O₁₆S

Molecular weight: 1422.7

Ref: ST-EA-CP-B106010