CAS 22609-73-0

Niludipine

Description:

Niludipine is a calcium channel blocker primarily used in the treatment of hypertension and certain types of angina. It belongs to the dihydropyridine class of calcium antagonists, which work by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac tissue. This action leads to vasodilation, reducing peripheral resistance and lowering blood pressure. Niludipine is characterized by its lipophilicity, which allows for good absorption and distribution in the body. It has a relatively long half-life, enabling once-daily dosing in clinical practice. The compound is typically administered in its oral form and is known for its selectivity for vascular smooth muscle over cardiac tissue, minimizing potential side effects such as reflex tachycardia. As with other medications in its class, niludipine may cause side effects including headache, flushing, and peripheral edema. It is important for patients to be monitored for these effects and for any interactions with other medications they may be taking.

Formula: C₂₅H₃₄N₂O₈

InChI: InChI=1/C25H34N2O8/c1-5-10-32-12-14-34-24(28)21-17(3)26-18(4)22(25(29)35-15-13-33-11-6-2)23(21)19-8-7-9-20(16-19)27(30)31/h7-9,16,23,26H,5-6,10-15H2,1-4H3

InChI key: InChIKey=VZWXXKDFACOXNT-UHFFFAOYSA-N

SMILES: C(OCCOCCC)(=O)C=1C(C(C(OCCOCCC)=O)=C(C)NC1C)C2=CC(N(=O)=O)=CC=C2

Synonyms:

• 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid Bis(2-propoxyethyl) Ester
• 245-120-6
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3,5-bis(2-propoxyethyl) ester
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, bis(2-propoxyethyl) ester
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-, bis(2-propoxyethyl) ester
• BAY-a 7168
• Bis(2-propoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• Niludipin
• Niludipine

Niludipine

CAS: 22609-73-0

Nirudipine is a potent calcium channel blocker and anti-angina drug, effective for various anginas, ischemic heart disease, and hypertension.

Formula: C₂₅H₃₄N₂O₈

Color and Shape: Solid

Molecular weight: 490.55

Ref: TM-T33673