CAS 2262452-06-0

3-(1-(6,7-Dichloro-1H-benzo[d]imidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl)isobenzofuran-1(3H)-one

CAS: 2262452-06-0

Formula: C₁₉H₁₂Cl₂N₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 415.2296

Ref: IN-DA01LIF0

RU.521

CAS: 2262452-06-0

RU.521

Purity: ≥98%

Molecular weight: 415.23g/mol

Ref: 54-BUP04909

RU-521

CAS: 2262452-06-0

RU-521

Purity: 98%

Molecular weight: 415.2g/mol

Ref: 54-OR1023263

RU.521

CAS: 2262452-06-0

RU.521 (RU3205217) is a selective cyclic GMP-AMP synthetase (cGAS) inhibitor (mouse: IC50=0.11 μM), (human: IC50=2.94 μM). High-Quality, Low-Cost!

Formula: C₁₉H₁₂Cl₂N₄O₃

Purity: 98% - 99.78%

Color and Shape: Solid

Molecular weight: 415.23

Ref: TM-T5486

RU.521

CAS: 2262452-06-0

RU.521 is a novel cytosolic inhibitor of autophagy that has been shown to activate the innate immune response and promote chronic pulmonary inflammation in animal models. The molecule binds to toll-like receptor 4 (TLR4) on human macrophages and elicits the release of tumor necrosis factor alpha (TNFα), IL-1β, and IL-6, which are proinflammatory cytokines that promote the activation of dendritic cells. This compound also induces polymerase chain reaction (PCR)-amplified mRNA transcripts encoding TLR4 in primary cells. RU.521 is also able to stop neuronal death in experimental models of Parkinson's disease by restoring mitochondrial function and inhibiting caspase 3 activation.

Formula: C₁₉H₁₂Cl₂N₄O₃

Purity: Min. 95%

Molecular weight: 415.23 g/mol

Ref: 3D-MQD45206