CAS 226256-56-0

Cinacalcet

Description:

Cinacalcet is a synthetic compound primarily used as a medication to manage secondary hyperparathyroidism in patients with chronic kidney disease on dialysis and to treat hypercalcemia in patients with parathyroid carcinoma. It functions as a calcimimetic agent, which means it enhances the sensitivity of calcium-sensing receptors on parathyroid cells, thereby reducing parathyroid hormone (PTH) secretion and lowering serum calcium levels. The chemical formula of cinacalcet is C22H28N2O2S, and it has a molecular weight of approximately 372.54 g/mol. Cinacalcet is typically administered orally and is known for its relatively high bioavailability. Its pharmacokinetics indicate that it is extensively metabolized in the liver, primarily by cytochrome P450 enzymes. Common side effects may include nausea, vomiting, and hypocalcemia. As with any medication, it is essential for patients to be monitored for potential adverse effects and to ensure appropriate dosing. Overall, cinacalcet represents a significant advancement in the management of disorders related to calcium and parathyroid hormone regulation.

Formula: C₂₂H₂₂F₃N

InChI: InChI=1S/C22H22F3N/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3/t16-/m1/s1

InChI key: InChIKey=VDHAWDNDOKGFTD-MRXNPFEDSA-N

SMILES: [C@@H](NCCCC1=CC(C(F)(F)F)=CC=C1)(C)C=2C3=C(C=CC2)C=CC=C3

Synonyms:

• (αR)-α-Methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine
• 1-Naphthalenemethanamine, α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-, (αR)-
• Amg 073
• Cinacalcel
• N-((1R)-1-(1-Naphthyl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine
• N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine
• N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride (1:1)
• Parareg
• Cinacalcet

Cinacalcet

CAS: 226256-56-0

Cinacalcet

Purity: 98%

Molecular weight: 357.42g/mol

Ref: 54-PC109020

Cinacalcet

CAS: 226256-56-0

Cinacalcet

Purity: ≥98%

Molecular weight: 357.41g/mol

Ref: 54-BUP13774

Cinacalcet

CAS: 226256-56-0

Cinacalcet (AMG 073) is an orally active, allosteric Ca receptor (CaR) agonist, treatment of cardiovascular disease .

Formula: C₂₂H₂₂F₃N

Purity: 99.48%

Color and Shape: Yellow Oil

Molecular weight: 357.41

Ref: TM-T8403

(R)-N-(1-(NAPHTHALEN-1-YL)ETHYL)-3-(3-(TRIFLUOROMETHYL)PHENYL)PROPAN-1-AMINE

CAS: 226256-56-0

Purity: 99%

Molecular weight: 357.4200134

Ref: 10-F859016

Cinacalcet

Controlled Product

CAS: 226256-56-0

Applications Cinacalcet is the first calcimimetic drug approved by the United States Food and Drug Administration for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease.
References Block, G, et al.: Am. J. Kidney Dis., 35, 1226 (2000), Moe, S., et al.: Am. J. Nephrol., 23, 369 (2003), Block, G., et al.: J. Am. Soc. Nephrol., 15, 2208 (2004).

Formula: C₂₂H₂₂F₃N

Color and Shape: Neat

Molecular weight: 357.41

Ref: TR-C441790