CAS 2265-22-7

Dexamethasone 21-mesylate

Description:

Dexamethasone 21-mesylate is a synthetic glucocorticoid and a derivative of dexamethasone, primarily used for its anti-inflammatory and immunosuppressive properties. It is characterized by its mesylate group, which enhances its solubility and bioavailability. The compound is typically a white to off-white crystalline powder, and it is soluble in organic solvents such as methanol and dimethyl sulfoxide, but has limited solubility in water. Dexamethasone 21-mesylate acts by binding to glucocorticoid receptors, leading to the modulation of gene expression and subsequent biological effects, including the reduction of inflammation and suppression of immune responses. It is commonly utilized in various medical applications, including the treatment of conditions like allergies, autoimmune disorders, and certain types of cancer. Safety and efficacy profiles are well-documented, but like all corticosteroids, it may have side effects, particularly with long-term use. Proper dosage and administration are crucial to minimize potential adverse effects.

Formula: C₂₃H₃₁FO₇S

InChI: InChI=1S/C23H31FO7S/c1-13-9-17-16-6-5-14-10-15(25)7-8-20(14,2)22(16,24)18(26)11-21(17,3)23(13,28)19(27)12-31-32(4,29)30/h7-8,10,13,16-18,26,28H,5-6,9,11-12H2,1-4H3/t13-,16+,17+,18+,20+,21+,22+,23+/m1/s1

InChI key: InChIKey=ATNWRUJPJUBMHC-HOGMHMTRSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](F)([C@]4(C)C(CC3)=CC(=O)C=C4)[C@@H](O)C1)[H])(C[C@@H](C)[C@@]2(C(COS(C)(=O)=O)=O)O)[H]

Synonyms:

• (11β,16α)-9-Fluoro-11,17-dihydroxy-16-methyl-21-[(methylsulfonyl)oxy]pregna-1,4-diene-3,20-dione
• Dexamethasone 21-mesylate
• Dexamethasone 21-methanesulfonate
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-((methylsulfonyl)oxy)-, (11beta,16alpha)-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-[(methylsulfonyl)oxy]-, (11β,16α)-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-methanesulfonate

dexamethasone 21-methanesulfonate

CAS: 2265-22-7

Formula: C₂₃H₃₁FO₇S

Purity: 95%

Color and Shape: Solid

Molecular weight: 470.5514

Ref: IN-DA00BHU7

Dexamethasone 21-Mesylate

Controlled Product

CAS: 2265-22-7

Stability Moisture Sensitive
Applications Dexamethasone 21-Mesylate is a derivative of Dexamethasone (D298800), a glucocorticoid used as an anti-inflammatory agent.
References Kim, T.H., et al.: J. Nanosci. Nanotech., 13, 7325 (2013); Joshi, T., et al.: Brit. J. Pharmacol., 172, 1360 (2015);

Formula: C₂₃H₃₁FO₇S

Color and Shape: Neat

Molecular weight: 470.55

Ref: TR-D298885

Dexamethasone 21-mesylate

CAS: 2265-22-7

Dexamethasone 21-mesylate is a glucocorticoid that is used to treat a variety of inflammatory conditions. It has been shown to inhibit the phosphatase activity of human placental cells in tissue culture and to inhibit the synthesis of heat-shock proteins. Dexamethasone 21-mesylate also inhibits the synthesis of prostaglandins, which are potent mediators of inflammation. Dexamethasone 21-mesylate has been shown to have a nonsaturable inhibitory effect on two different types of activated lymphocytes, which may be due to its ability to bind with high affinity to glucocorticoid receptors.

Formula: C₂₃H₃₁FO₇S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 470.6 g/mol

Ref: 3D-CAA26522

Dexamethasone 21-Mesylate

CAS: 2265-22-7

Formula: C₂₃H₃₁FO₇S

Molecular weight: 470.55

Ref: ST-EA-CP-D17052