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CAS 2265-64-7

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Dexamethasone 21-isonicotinate

Description:
Dexamethasone 21-isonicotinate is a synthetic corticosteroid derivative, primarily known for its anti-inflammatory and immunosuppressive properties. It is a modification of dexamethasone, which is widely used in the treatment of various conditions, including allergies, autoimmune diseases, and certain cancers. The addition of the isonicotinate moiety enhances its pharmacological profile, potentially improving its therapeutic efficacy and bioavailability. This compound typically exhibits high solubility in organic solvents and moderate solubility in water, which can influence its formulation in pharmaceutical applications. Dexamethasone 21-isonicotinate is characterized by its ability to bind to glucocorticoid receptors, leading to the modulation of gene expression and subsequent biological effects. Its use in clinical settings is often associated with a range of side effects, including potential impacts on metabolism, immune response, and endocrine function. As with all corticosteroids, careful consideration of dosage and duration of treatment is essential to minimize adverse effects while maximizing therapeutic benefits.
Formula:C28H32FNO6
InChI:InChI=1S/C28H32FNO6/c1-16-12-21-20-5-4-18-13-19(31)6-9-25(18,2)27(20,29)22(32)14-26(21,3)28(16,35)23(33)15-36-24(34)17-7-10-30-11-8-17/h6-11,13,16,20-22,32,35H,4-5,12,14-15H2,1-3H3/t16-,20+,21+,22+,25+,26+,27+,28+/m1/s1
InChI key:InChIKey=BQTXJHAJMDGOFI-NJLPOHDGSA-N
SMILES:C[C@@]12[C@]([C@]3([C@@](F)([C@]4(C)C(CC3)=CC(=O)C=C4)[C@@H](O)C1)[H])(C[C@@H](C)[C@@]2(C(COC(=O)C=5C=CN=CC5)=O)O)[H]
Synonyms:
  • (11Beta,16Alpha)-9-Fluoro-11,17-Dihydroxy-16-Methyl-3,20-Dioxopregna-1,4-Dien-21-Yl Pyridine-4-Carboxylate
  • (11β,16α)-9-Fluoro-11,17-dihydroxy-16-methyl-21-[(4-pyridinylcarbonyl)oxy]pregna-1,4-diene-3,20-dione
  • Alin Depot
  • Ausixone
  • Auxiloson
  • Dexamethasone 21-(4-pyridinecarboxylate)
  • Dexamethasone Isonicotinate
  • He 111
  • Isonicotinic acid dexamethasone-21 ester
  • Isonicotinic acid, 21-ester with 9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
  • See more synonyms
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Found 7 products.