CAS 22668-01-5

Etanidazole

Description:

Etanidazole is a synthetic compound primarily known for its application as an antiprotozoal agent, particularly in the treatment of infections caused by anaerobic bacteria and certain protozoa. It belongs to the class of nitroimidazoles, which are characterized by their nitro group attached to an imidazole ring. This structure is crucial for its biological activity, as it allows the compound to undergo reduction in anaerobic conditions, leading to the generation of reactive intermediates that can damage microbial DNA. Etanidazole is typically administered orally and is known for its relatively low toxicity in humans, making it a preferred choice in certain therapeutic contexts. The compound is soluble in organic solvents but has limited solubility in water, which can influence its pharmacokinetics. Additionally, it is important to note that, like other nitroimidazoles, etanidazole may exhibit side effects, including gastrointestinal disturbances and potential interactions with alcohol, leading to disulfiram-like reactions. Overall, etanidazole's unique chemical properties and mechanism of action make it a valuable agent in the field of infectious disease treatment.

Formula: C₇H₁₀N₄O₄

InChI: InChI=1S/C7H10N4O4/c12-4-2-8-6(13)5-10-3-1-9-7(10)11(14)15/h1,3,12H,2,4-5H2,(H,8,13)

InChI key: InChIKey=WCDWBPCFGJXFJZ-UHFFFAOYSA-N

SMILES: N(=O)(=O)C=1N(CC(NCCO)=O)C=CN1

Synonyms:

• 1H-Imidazole-1-acetamide, N-(2-hydroxyethyl)-2-nitro-
• Brn 0919296
• Etanidazol
• Etanidazol [Spanish]
• Etanidazole (SR-2508)
• Etanidazole [USAN:INN]
• Etanidazolum
• Etanidazolum [Latin]
• Ethanidazole
• Imidazole-1-acetamide, N-(2-hydroxyethyl)-2-nitro-
• N-(2-Hydroxyethyl)-1-(2-nitro-1-imidazolyl)acetamide
• N-(2-Hydroxyethyl)-2-nitro-1H-imidazole-1-acetamide
• N-(2-Hydroxyethyl)-2-nitroimidazole-1-acetamide
• N-(2-hydroxyethyl)-2-(2-nitro-1H-imidazol-1-yl)acetamide
• NSC 301-467
• Nsc 301467
• Radinyl
• Sr 2508
• Unii-30Dka3Q1Hl
• Etanidazole

Etanidazole

CAS: 22668-01-5

Formula: C₇H₁₀N₄O₄

Molecular weight: 214.18

Ref: 4Z-E-251001

Etanidazole

Controlled Product

CAS: 22668-01-5

Stability Hygroscopic
Applications Etanidazole is a kind of hypoxic radiosensitizer (a drug that sensitizes tumour cells to radiation therapy). Etanidazole is used in conjunction with Paclitaxel (P132500) to treat glioma, and is also used with Carboplatin (C177500) to treat advanced ovarian cancer.
References Brown, M.: Cancer Res., 59, 5863 (1999); Kumar, N., et al.: Biomaterials, 28, 886 (2007); Shulman, L., et al.: Int. J. Radiat. Oncol., 29, 545 (1994); Wang, F. & Wang, C.: J. Control. Release, 81, 263 (2002)

Formula: C₇H₁₀N₄O₄

Color and Shape: Neat

Molecular weight: 214.18

Ref: TR-E889230

Etanidazole

CAS: 22668-01-5

Etanidazole (SR-2508) is a radiosensitizing 2-nitroimidazole that targets glutathione, aiding in cancer imaging and treatment.

Formula: C₇H₁₀N₄O₄

Color and Shape: Solid

Molecular weight: 214.18

Ref: TM-T69714