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CAS 226700-79-4

:

Fosamprenavir

Description:
Fosamprenavir is an antiretroviral medication primarily used in the treatment of HIV infection. It is a prodrug of amprenavir, meaning it is metabolized in the body to produce the active form. Fosamprenavir is classified as a non-nucleoside reverse transcriptase inhibitor (NNRTI) and works by inhibiting the reverse transcriptase enzyme, which is crucial for viral replication. The substance is typically administered orally and is often combined with other antiretroviral agents to enhance efficacy and reduce the risk of resistance. In terms of its chemical characteristics, fosamprenavir has a molecular formula that includes carbon, hydrogen, nitrogen, oxygen, and sulfur atoms, contributing to its complex structure. It is known for its relatively high solubility in organic solvents and moderate solubility in water. Common side effects may include gastrointestinal disturbances, rash, and potential interactions with other medications due to its metabolism via the cytochrome P450 system. Overall, fosamprenavir plays a significant role in HIV treatment regimens, particularly in patients with specific resistance patterns.
Formula:C25H36N3O9PS
InChI:InChI=1S/C25H36N3O9PS/c1-18(2)15-28(39(33,34)22-10-8-20(26)9-11-22)16-24(37-38(30,31)32)23(14-19-6-4-3-5-7-19)27-25(29)36-21-12-13-35-17-21/h3-11,18,21,23-24H,12-17,26H2,1-2H3,(H,27,29)(H2,30,31,32)/t21-,23-,24+/m0/s1
InChI key:InChIKey=MLBVMOWEQCZNCC-OEMFJLHTSA-N
SMILES:[C@H]([C@H](CC1=CC=CC=C1)NC(O[C@H]2CCOC2)=O)(CN(S(=O)(=O)C3=CC=C(N)C=C3)CC(C)C)OP(=O)(O)O
Synonyms:
  • GW 433908
  • Carbamic acid, N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)-2-(phosphonooxy)propyl]-, C-[(3S)-tetrahydro-3-furanyl] ester
  • GW 433 908
  • Fosamprenavir
  • Carbamic acid, [(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)-2-(phosphonooxy)propyl]-, C-[(3S)-tetrahydro-3-furanyl] ester
  • 226700-79-4
  • Amprenavir phosphate
  • Fosamprenavir
  • ((1S,2R)-3-(((4-Aminophenyl)sulfonyl)(2-methylpropyl)amino)-1-(phenylmethyl)-2-(phosphonooxy)propyl)carbamic Acid C-((3S)-Tetrahydro-3-furanyl) Ester
  • (3S)-Tetrahydrofuran-3-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](isobutyl)amino}-1-phenyl-3-(phosphonooxy)butan-2-yl]carbamate
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