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CAS 2270232-93-2

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Obeticholic acid 3-O-β-D-glucuronide

Description:
Obeticholic acid 3-O-β-D-glucuronide is a metabolite of obeticholic acid, a bile acid derivative used primarily in the treatment of liver diseases, particularly primary biliary cholangitis. This compound is characterized by its glucuronide conjugation, which enhances its solubility and facilitates excretion. The structure features a steroid backbone typical of bile acids, modified by the addition of a glucuronic acid moiety at the 3-position, which is a common metabolic pathway for many drugs and endogenous compounds. This modification generally increases the compound's polarity, affecting its pharmacokinetics and bioavailability. Obeticholic acid itself acts as a farnesoid X receptor (FXR) agonist, influencing bile acid homeostasis and lipid metabolism. The glucuronide form may exhibit altered biological activity compared to its parent compound, potentially impacting its therapeutic efficacy and safety profile. Understanding the characteristics of this metabolite is crucial for evaluating its role in pharmacology and toxicology, particularly in the context of liver function and disease management.
Synonyms:
  • Obeticholic acid 3-O-β-D-glucuronide
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