CAS 227083-47-8

Cyclo[N-methyl-L-α-aspartyl-N-methyl-L-isoleucyl-N-methyl-L-isoleucylglycyl-N-methyl-L-valyl-O-methyl-L-tyrosyl-(2R)-2-hydroxy-3-methylbutanoyl-(2S)-2-piperidinecarbonyl-N-methyl-L-valyl-L-valyl] (9CI)

Description:

Cyclo[N-methyl-L-α-aspartyl-N-methyl-L-isoleucyl-N-methyl-L-isoleucylglycyl-N-methyl-L-valyl-O-methyl-L-tyrosyl-(2R)-2-hydroxy-3-methylbutanoyl-(2S)-2-piperidinecarbonyl-N-methyl-L-valyl-L-valyl] (9CI), with CAS number 227083-47-8, is a synthetic cyclic peptide characterized by its complex structure comprising multiple amino acid residues and modifications. This compound features N-methylation of several amino acids, which can enhance its stability and bioavailability. The presence of a piperidinecarbonyl group and a hydroxy-3-methylbutanoyl moiety suggests potential interactions with biological targets, making it of interest in medicinal chemistry. Its cyclic nature may confer unique conformational properties, influencing its biological activity and interaction with receptors or enzymes. The compound's synthesis likely involves advanced peptide coupling techniques and may require careful control of stereochemistry due to the presence of chiral centers. Overall, this substance exemplifies the intricate design often employed in the development of peptide-based therapeutics, aiming to optimize efficacy and reduce degradation in biological systems.

Formula: C₅₉H₉₅N₉O₁₄

Synonyms:

• Cyclo[N-methyl-L-α-aspartyl-N-methyl-L-isoleucyl-N-methyl-L-isoleucylglycyl-N-methyl-L-valyl-O-methyl-L-tyrosyl-(2R)-2-hydroxy-3-methylbutanoyl-(2S)-2-piperidinecarbonyl-N-methyl-L-valyl-L-valyl] (9CI)

Clavariopsin A

CAS: 227083-47-8

Clavariopsin A is a cyclic peptide antibiotic with antifungal properties. It exhibits activity against Candida albicans (IFO 0583 and ATCC 10231), Aspergillus niger (AJ117374), Aspergillus fumigatus (AJ117190), and Aspergillus fumigatus (JCM1739) with minimum inhibitory concentrations (MIC) of 8, 8, 16, 2, and 4 μg/mL, respectively.

Formula: C₅₉H₉₅N₉O₁₄

Color and Shape: Solid

Molecular weight: 1154.44

Ref: TM-TN10497