CAS 227083-48-9

Cyclo[N-methyl-L-α-aspartyl-N-methyl-L-isoleucyl-N-methyl-L-isoleucylglycyl-N-methyl-L-valyl-O-methyl-L-tyrosyl-(2R)-2-hydroxy-3-methylbutanoyl-(2S)-2-piperidinecarbonyl-L-valyl-L-valyl] (9CI)

Description:

Cyclo[N-methyl-L-α-aspartyl-N-methyl-L-isoleucyl-N-methyl-L-isoleucylglycyl-N-methyl-L-valyl-O-methyl-L-tyrosyl-(2R)-2-hydroxy-3-methylbutanoyl-(2S)-2-piperidinecarbonyl-L-valyl-L-valyl] is a cyclic peptide with a complex structure characterized by multiple N-methylated amino acids and a unique side chain configuration. This compound features a cyclic arrangement that contributes to its stability and potential biological activity. The presence of N-methyl groups enhances its resistance to enzymatic degradation, making it of interest in pharmaceutical applications. The incorporation of various amino acids, including aspartic acid, isoleucine, valine, and tyrosine, suggests potential interactions with biological targets, possibly influencing receptor binding or enzyme activity. The specific stereochemistry indicated by the (2R) and (2S) designations further suggests that the compound may exhibit chiral properties, which can affect its pharmacokinetics and pharmacodynamics. Overall, this compound's intricate structure and modifications position it as a candidate for research in medicinal chemistry and drug development.

Formula: C₅₈H₉₃N₉O₁₄

Synonyms:

• Cyclo[N-methyl-L-α-aspartyl-N-methyl-L-isoleucyl-N-methyl-L-isoleucylglycyl-N-methyl-L-valyl-O-methyl-L-tyrosyl-(2R)-2-hydroxy-3-methylbutanoyl-(2S)-2-piperidinecarbonyl-L-valyl-L-valyl] (9CI)

Clavariopsin B

CAS: 227083-48-9

Clavariopsin B is a cyclic peptide antibiotic exhibiting antifungal activity. It is effective against Candida albicans [IFO 0583], Candida albicans [ATCC 10231], Aspergillus niger [AJ117374], Aspergillus fumigatus [AJ117190], and Aspergillus fumigatus [JCM1739], with minimum inhibitory concentrations (MICs) of 8, 8, 16, 4, and 4 μg/mL respectively.

Formula: C₅₈H₉₃N₉O₁₄

Color and Shape: Solid

Molecular weight: 1140.41

Ref: TM-TN10283