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CAS 22832-87-7

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Miconazole nitrate

Description:
Miconazole nitrate is an antifungal agent commonly used in the treatment of various fungal infections, particularly those affecting the skin and mucous membranes. It belongs to the imidazole class of antifungals and works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting their integrity and function. Miconazole nitrate is typically available in various formulations, including creams, powders, and vaginal suppositories, making it versatile for different applications. The substance is characterized by its white to off-white crystalline powder form, with a relatively low solubility in water but better solubility in organic solvents. It is generally well-tolerated, though some individuals may experience local irritation or allergic reactions. Miconazole nitrate is also notable for its broad-spectrum activity against a range of fungi, including dermatophytes and yeasts, making it effective for conditions such as athlete's foot, ringworm, and candidiasis. Its mechanism of action and efficacy have made it a staple in both over-the-counter and prescription antifungal therapies.
Formula:C18H14Cl4N2O·HNO3
InChI:InChI=1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)
InChI key:InChIKey=MCCACAIVAXEFAL-UHFFFAOYSA-N
SMILES:C(CN1C=CN=C1)(OCC2=C(Cl)C=C(Cl)C=C2)C3=C(Cl)C=C(Cl)C=C3.N(=O)(=O)O
Synonyms:
  • 1-(2,4-Dichloro-Beta-[(2,4-Dichlorobenzyl)Oxy]Phenethyl)Imidazole Nitrate
  • 1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
  • 1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole nitrate (1:1)
  • 1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-, mononitrate
  • 1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-, nitrate (1:1)
  • Aflorix
  • Albistat
  • Andergin
  • Antifungal Cream
  • Brentan
  • See more synonyms
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