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CAS 22875-15-6

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Leucomycin V

Description:
Leucomycin V is a macrolide antibiotic that is derived from the fermentation of the bacterium *Streptomyces aureofaciens*. It is characterized by its complex structure, which includes a large lactone ring and multiple sugar moieties, contributing to its biological activity. Leucomycin V exhibits antibacterial properties, particularly against Gram-positive bacteria, making it effective in treating various infections. Its mechanism of action involves inhibiting bacterial protein synthesis by binding to the 50S ribosomal subunit, similar to other macrolides. The compound is known for its stability in acidic conditions, which enhances its bioavailability. Additionally, Leucomycin V may have a lower toxicity profile compared to some other antibiotics, making it a valuable option in clinical settings. However, like other antibiotics, it can lead to resistance if misused. Its chemical formula and specific stereochemistry contribute to its pharmacological properties, and ongoing research continues to explore its potential applications and derivatives in medicine.
Formula:C35H59NO13
InChI:InChI=1S/C35H59NO13/c1-19-16-23(14-15-37)31(32(44-8)25(39)17-26(40)45-20(2)12-10-9-11-13-24(19)38)49-34-29(41)28(36(6)7)30(21(3)47-34)48-27-18-35(5,43)33(42)22(4)46-27/h9-11,13,15,19-25,27-34,38-39,41-43H,12,14,16-18H2,1-8H3/b10-9+,13-11+/t19-,20-,21-,22+,23+,24+,25-,27+,28-,29-,30-,31+,32+,33+,34+,35-/m1/s1
InChI key:InChIKey=XYJOGTQLTFNMQG-KJHBSLKPSA-N
SMILES:O([C@H]1[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@@H]1OC)[C@H]2[C@H](O)[C@@H](N(C)C)[C@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H](C)O2
Synonyms:
  • Deacylleucomycin A1
  • Deisovalerylleucomycin A1
  • Oxacyclohexadeca-11,13-diene-7-acetaldehyde, 6-[[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-a-L-ribo-hexopyranosyl)-3-(dimethylamino)-b-D-glucopyranosyl]oxy]-4,10-dihydroxy-5-methoxy-9,16-dimethyl-2-oxo-,[4R-(4R*,5S*,6S*,7R*,9R*,10R*,11E,13E,16R*)]-
  • Oxacyclohexadecane, leucomycin V deriv.
  • Glucopyranoside,7-(formylmethyl)-4,10-dihydroxy-5-methoxy-9,16-dimethyl-2-oxooxacyclohexadeca-11,13-dien-6-yl3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-a-L-ribo-hexopyranosyl)-3-(dimethylamino)-, b-D- (8CI)
  • Deacylleucomycin A1
  • Glucopyranoside, 7-(formylmethyl)-4,10-dihydroxy-5-methoxy-9,16-dimethyl-2-oxooxacyclohexadeca-11,13-dien-6-yl 3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-3-(dimethylamino)-, β-D-
  • Leucomycin V
  • Turimycin H0
  • Oxacyclohexadecane,leucomycin V deriv.
  • See more synonyms
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