CAS 22889-78-7

4-Amino-3,5-dichloropyridine

Description:

4-Amino-3,5-dichloropyridine is an organic compound characterized by its pyridine ring, which is a six-membered aromatic heterocycle containing one nitrogen atom. This compound features two chlorine substituents at the 3 and 5 positions and an amino group at the 4 position of the pyridine ring. Its molecular formula is C5H4Cl2N2, and it has a relatively low molecular weight. The presence of the amino group makes it a potential candidate for various chemical reactions, including nucleophilic substitutions and coupling reactions. 4-Amino-3,5-dichloropyridine is typically a solid at room temperature and may exhibit moderate solubility in polar solvents. It is often used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds due to its functional groups that can participate in further chemical transformations. Safety precautions should be taken when handling this compound, as it may pose health risks if ingested or inhaled, and appropriate measures should be followed to mitigate exposure.

Formula: C₅H₄Cl₂N₂

InChI: InChI=1S/C5H4Cl2N2/c6-3-1-9-2-4(7)5(3)8/h1-2H,(H2,8,9)

InChI key: InChIKey=ISIQAMHROGZHOV-UHFFFAOYSA-N

SMILES: NC=1C(Cl)=CN=CC1Cl

Synonyms:

• 3,5-Dichloro-4-amino pyridine
• 3,5-Dichloro-4-aminopyridine
• 3,5-Dichloro-4-pyridinamine
• 3,5-Dichloropyridin-4-Amine
• 3,5-Dichloropyridin-4-ylamine
• 3,5-Dichloropyridine-4-amine
• 4-Amino-3,5-Dichloropyridinium
• 4-Pyridinamine, 3,5-dichloro-
• Aminodichloropyridine
• Pyridine, 4-amino-3,5-dichloro-
• Roflumilast intermediates-5

4-Amino-3,5-dichloropyridine

CAS: 22889-78-7

Formula: C₅H₄Cl₂N₂

Purity: >98.0%(GC)(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 163.00

Ref: 3B-A1545

4-Amino-3,5-dichloropyridine, 97%

CAS: 22889-78-7

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₅H₄Cl₂N₂

Purity: 97%

Color and Shape: White to cream, Crystals or powder or crystalline powder

Molecular weight: 163.00

Ref: 02-B24725

Roflumilast Related Compound C (3,5-Dichloropyridin-4-amine)

CAS: 22889-78-7

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₅H₄Cl₂N₂

Color and Shape: White Yellow Powder

Molecular weight: 161.97515

Ref: 45-1605045

4-Pyridinamine, 3,5-dichloro-

CAS: 22889-78-7

Formula: C₅H₄Cl₂N₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 163.0047

Ref: IN-DA002LD3

Roflumilast USP Related Compound C

CAS: 22889-78-7

Formula: C₅H₄Cl₂N₂

Molecular weight: 163.01

Ref: 4Z-R-3733

4-Amino-3,5-dichloropyridine

CAS: 22889-78-7

Formula: C₅H₄Cl₂N₂

Molecular weight: 163.01

Ref: 7W-GK0336

4-Amino-3,5-dichloropyridine

CAS: 22889-78-7

4-Amino-3,5-dichloropyridine

Formula: C₅H₄Cl₂N₂

Purity: 98%

Color and Shape: white solid

Molecular weight: 163.00g/mol

Ref: 54-OR27150

4-Amino-3,5-dichloropyridine

CAS: 22889-78-7

Applications 4-Amino-3,5-dichloropyridine is a metabolite of the selective phosphodiesterase 4 (PDE4) inhibitor, Roflumilast (R639700).
References Jeffrey, A.D. et al.: Drug Chem. Toxicol., 25, 93 (2002); Cassidy, K.C. et al.: J. Pharmac. Biomed. Anal., 22, 869 (2000);

Formula: C₅H₄Cl₂N₂

Color and Shape: Neat

Molecular weight: 163.0

Ref: TR-A604705

Roflumilast USP Related Compound C

CAS: 22889-78-7

Formula: C₅H₄Cl₂N₂

Molecular weight: 163.00

Ref: ST-EA-CP-R29002

3,5-Dichloro-4-pyridine amine

CAS: 22889-78-7

Formula: C₅H₄Cl₂N₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 163

Ref: 10-F024644

4-Amino-3,5-dichloropyridine

CAS: 22889-78-7

4-Amino-3,5-dichloropyridine is a synthetic chemical that has been shown to have antibacterial activity in vitro. This drug inhibits the synthesis of enzymes that are necessary for the production of fatty acids and cholesterol by acting as an inhibitor of the enzyme chlorohydrolase. It also prevents the activation of chloride ions and can be used to treat chronic bronchitis and chronic pulmonary diseases. 4-Amino-3,5-dichloropyridine has been shown to be effective against gram negative bacteria, such as Salmonella typhimurium, Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis. It is also active against Mycobacterium tuberculosis, which is a slow growing organism with a high resistance to antibiotics.

Formula: C₅H₄Cl₂N₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 163 g/mol

Ref: 3D-FA16332