CAS 22994-85-0

Benznidazole

Description:

Benznidazole is a nitroimidazole derivative primarily used as an antiparasitic agent, particularly in the treatment of Chagas disease caused by the Trypanosoma cruzi parasite. It exhibits a molecular formula of C12H10N4O5S and has a molecular weight of approximately 298.3 g/mol. The compound is characterized by its nitro group, which is essential for its biological activity, and a thiazole ring that contributes to its pharmacological properties. Benznidazole is typically administered orally and is known for its ability to inhibit the growth of the parasite by interfering with its metabolic processes. The drug is generally well-tolerated, although it may cause side effects such as allergic reactions, gastrointestinal disturbances, and neurological symptoms in some patients. Its mechanism of action involves the generation of reactive oxygen species, leading to oxidative stress in the parasite. Benznidazole is an important therapeutic option in regions where Chagas disease is endemic, and ongoing research continues to explore its efficacy and safety profile in various populations.

Formula: C₁₂H₁₂N₄O₃

InChI: InChI=1S/C12H12N4O3/c17-11(14-8-10-4-2-1-3-5-10)9-15-7-6-13-12(15)16(18)19/h1-7H,8-9H2,(H,14,17)

InChI key: InChIKey=CULUWZNBISUWAS-UHFFFAOYSA-N

SMILES: C(C(NCC1=CC=CC=C1)=O)N2C(N(=O)=O)=NC=C2

Synonyms:

• 1H-Imidazole-1-acetamide, 2-nitro-N-(phenylmethyl)-
• 2-Nitro-N-(phenylmethyl)-1H-imidazole-1-acetamide
• Benznidazol
• Benzonidazol
• Benzonidazole
• Imidazole-1-acetamide, N-benzyl-2-nitro-
• N-Benzyl-2-nitroimidazol-1-yl-acetamide
• N-benzyl-2-(2-nitro-1H-imidazol-1-yl)acetamide
• N-benzyl-2-nitro-1H-imidazole-1-acetamide
• NSC 299972
• Radanil
• Ro 07-1051
• Ro 71051
• Rochagan

1H-Imidazole-1-acetamide, 2-nitro-N-(phenylmethyl)-

CAS: 22994-85-0

Formula: C₁₂H₁₂N₄O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 260.2487

Ref: IN-DA002LSW

Benznidazol

CAS: 22994-85-0

Benznidazol

Purity: ≥98%

Molecular weight: 260.25g/mol

Ref: 54-BUP11725

N-Benzyl-2-Nitro-1H-Imidazole-1-Acetamide

CAS: 22994-85-0

N-Benzyl-2-Nitro-1H-Imidazole-1-Acetamide

Purity: 97%

Molecular weight: 260.25g/mol

Ref: 54-OR1014261

Benznidazole

CAS: 22994-85-0

Formula: C₁₂H₁₂N₄O₃

Color and Shape: Off-White Solid

Molecular weight: 260.25

Ref: 4Z-B-082001

Benznidazole

CAS: 22994-85-0

Formula: C₁₂H₁₂N₄O₃

Molecular weight: 260.25

Ref: 7W-GP4377

Benznidazol

CAS: 22994-85-0

Benznidazol (Benznidazole)e has an antiprotozoal activity by interfering with parasite protein biosynthesis, influencing cytokines production and stimulating

Formula: C₁₂H₁₂N₄O₃

Purity: 99.53% - >99.99%

Color and Shape: Solid

Molecular weight: 260.25

Ref: TM-T4982

Benznidazole

CAS: 22994-85-0

Applications Benznidazole (BNZ) is traditionally used to treat Chagas disease caused by Trypanosoma cruzi. The drugs used for the treatment of this disease, Nifurtimox and Benznidazole, are toxic and present severe side effects.
References Abuin, G., et al.: Mol. Biochem. Parasitol ., 35, 229 (1989), Arora, P., et al.: J. Biol. Chem., 270, 6042 (1995), Campos, M., et al.: J. Immunol., 167, 416 (2001), Faundez, M., et al.: Antimicrob. Agents Chemother., 49, 126 (2005),

Formula: C₁₂H₁₂N₄O₃

Color and Shape: Neat

Molecular weight: 260.25

Ref: TR-B197925

Benznidazole-d7

Controlled Product

CAS: 22994-85-0

Applications Benznidazole-D7 is a labelled analogue of Benznidazole (B197925).

Formula: C₁₂H₅D₇N₄O₃

Color and Shape: Neat

Molecular weight: 267.29

Ref: TR-B197927

Benznidazole

CAS: 22994-85-0

Benznidazole is an antiprotozoal agent and is used for the treatment of Chagas disease. It generates free radicals that damage the DNA and other cellular components of the parasite.

Formula: C₁₂H₁₂N₄O₃

Purity: Min. 97 Area-%

Color and Shape: White Powder

Molecular weight: 260.25 g/mol

Ref: 3D-FB64954

BENZNIDAZOLE

CAS: 22994-85-0

Purity: ≥97%

Molecular weight: 260.2529907

Ref: 10-F826141