CAS 229961-08-4

L-Phenylalanine,L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-

Description:

L-Phenylalanine, L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl- is a complex peptide composed of multiple amino acids, including L-phenylalanine, L-arginine, L-proline, L-leucine, L-serine, L-histidine, L-lysine, glycine, and L-methionine. This substance is characterized by its sequence of amino acids, which contributes to its specific biological functions and properties. Peptides like this one can exhibit various physiological activities, including roles in signaling, metabolism, and cellular communication. The presence of multiple arginine and proline residues may influence its structural stability and interactions with other biomolecules. Additionally, the CAS number 229961-08-4 uniquely identifies this compound in chemical databases, facilitating its study and application in research and therapeutic contexts. Overall, the characteristics of this peptide are determined by its amino acid composition, sequence, and the resulting three-dimensional structure, which are crucial for its biological activity.

Formula: C₆₄H₁₀₃N₂₁O₁₄S

Synonyms:

• 1: PN: US20080182274 SEQID: 1 claimedprotein
• 66-77-Apelin, prepro-
• 67: PN: WO2008058016 SEQID: 67 claimed protein
• 8: PN: WO2007072980 SEQID: 23claimed protein
• Apelin-12
• H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-Oh
• 6: PN: WO2005023863 SEQID: 6 claimed sequence
• 13: PN:WO03063892 SEQID: 44 unclaimed sequence

Apelin-12 (human, bovine, mouse, rat)

CAS: 229961-08-4

Apelin-12, RPRLSHKGPMPF, is an endogenous ligand of the human orphan receptor APJ and has been shown to reduce arterial blood pressure without producing a change in the heart rate in anesthetized rats. Its vasoactive effect might be exerted by activation of endothelial nitric oxide synthase.

Formula: C₆₄H₁₀₃N₂₁O₁₄S

Purity: 99.1%

Color and Shape: White Lyophilisate

Molecular weight: 1422.72

Ref: 01-4038636

Apelin-12 (human, bovine, mouse, rat)

CAS: 229961-08-4

Apelin-12 is a peptide hormone that belongs to the group of apelin family. It is an endogenous agonist for the apelin receptor and has been shown to affect metabolic and cardiovascular regulation. Apelin-12 has been found to increase systolic blood pressure, which may be due to its ability to inhibit the synthesis of nitric oxide in the heart. It also exhibits anti-inflammatory properties, which have been shown in vivo using a model of colitis induced by dextran sulfate sodium (DSS). The biological properties of this hormone are not yet fully understood. However, it is known that it has effects on cardiac contractility and myocardial infarct size in vivo. Further investigation into this protein's role in inflammatory diseases and metabolic disorders may lead to new treatments for these conditions.

Formula: C₆₄H₁₀₃N₂₁O₁₄S

Purity: Min. 95%

Molecular weight: 1,422.7 g/mol

Ref: 3D-FA109622