The chemical substance known as Boron, [4-[(1E)-2-[1,8-dihydro-8-(2H-pyrrol-2-ylidene-κN)cyclohepta[b]pyrrol-6-yl-κN]ethenyl]-N,N-dimethylbenzenaminato]difluoro-, (T-4)-, with CAS number 2301931-35-9, is a complex organoboron compound. It features a boron atom coordinated to a variety of organic ligands, including a dimethylaminobenzene moiety and a cycloheptapyrrole structure, which contributes to its unique chemical properties. The presence of difluoro substituents enhances its stability and reactivity, making it potentially useful in various applications, including materials science and organic synthesis. The intricate structure suggests that it may exhibit interesting electronic properties, possibly making it suitable for use in optoelectronic devices or as a catalyst in chemical reactions. Additionally, the presence of nitrogen-containing heterocycles indicates potential biological activity, warranting further investigation into its pharmacological properties. Overall, this compound exemplifies the diverse chemistry of boron and its ability to form complex, functionalized structures.

Neurofibrillary tangle BODIPY (600/710 nm) is a fluorescent probe for neurofibrillary tangles (NFTs).1 It binds to tau-K18 aggregates in a cell-free assay (Kd = 16.8 nM) and is 2.17-fold selective for tau-K18 aggregates over amyloid-β (1-42) (Aβ42) aggregates. NFT BODIPY (600/710 nm) has been used to label NFTs in postmortem hippocampus from patients with Alzheimer’s disease. It has been used to identify tauopathy in vivo and ex vivo in transgenic human tauP301L-expressing mice with a lower signal occurring in the brain of wild-type mice. NFT BODIPY (600/710 nm) displays excitation maxima ranging from 570 to 600 nm and emission maxima ranging from 710 to 774 nm in the solvents methylene chloride, THF, methanol, DMSO, and PBS.WARNING This product is not for human or veterinary use.

Boron, [4-[(1E)-2-[1,8-dihydro-8-(2H-pyrrol-2-ylidene-κN)cyclohepta[b]pyrrol-6-yl-κN]ethenyl]-N,N-dimethylbenzenaminato]difluoro-, (T-4)-

2301931-35-9: The chemical substance known as Boron, [4-[(1E)-2-[1,8-dihydro-8-(2H-pyrrol-2-ylidene-κN)cyclohepta[b]pyrrol-6-yl-κN]ethenyl]-N,N-dimethylbenzenaminato]difluoro-, (T-4)-, with CAS number 2301931-35-9, is a complex organoboron compound. It features a boron atom coordinated to a variety of organic ligands, including a dimethylaminobenzene moiety and a cycloheptapyrrole structure, which contributes to its unique chemical properties. The presence of difluoro substituents enhances its stability and reactivity, making it potentially useful in various applications, including materials science and organic synthesis. The intricate structure suggests that it may exhibit interesting electronic properties, possibly making it suitable for use in optoelectronic devices or as a catalyst in chemical reactions. Additionally, the presence of nitrogen-containing heterocycles indicates potential biological activity, warranting further investigation into its pharmacological properties. Overall, this compound exemplifies the diverse chemistry of boron and its ability to form complex, functionalized structures.

<p>TNIR7-1A is a fused cycloheptatriene-BODIPY derivative that is optimized for near-infrared (NIR) imaging characteristics (Ex/Em = 600/774 nm in PBS) and exhibits high affinity and specificity for neurofibrillary tangles (NFT) in vitro. Additionally, TNIR7-1A can effectively penetrate the blood-brain barrier.</p>

CAS 2301931-35-9

Boron, [4-[(1E)-2-[1,8-dihydro-8-(2H-pyrrol-2-ylidene-κN)cyclohepta[b]pyrrol-6-yl-κN]ethenyl]-N,N-dimethylbenzenaminato]difluoro-, (T-4)-

TNIR7-1A

Ref: TM-T203140