CAS 23025-68-5

angiotensin ii fragment 3-8 acetate,*human

Description:

Angiotensin II fragment 3-8 acetate, also known by its CAS number 23025-68-5, is a peptide that plays a significant role in the renin-angiotensin system, which regulates blood pressure and fluid balance. This specific fragment consists of a sequence of amino acids derived from the larger angiotensin II molecule, specifically encompassing the amino acids from positions 3 to 8. It is characterized by its ability to bind to angiotensin receptors, influencing vasoconstriction and aldosterone secretion, thereby impacting cardiovascular function. The acetate form indicates that the peptide is acetylated, which can enhance its stability and solubility in biological systems. Typically, angiotensin II fragments are studied for their physiological effects, including their role in hypertension and heart failure. In laboratory settings, this peptide is often utilized in research to explore its biological activity and potential therapeutic applications. As with many peptides, it is important to handle it under appropriate conditions to maintain its integrity and biological activity.

Formula: C₄₀H₅₄N₈O₈

InChI: InChI=1/C40H54N8O8/c1-5-24(4)34(47-35(50)29(44-37(52)33(41)23(2)3)18-26-13-15-28(49)16-14-26)38(53)45-30(20-27-21-42-22-43-27)39(54)48-17-9-12-32(48)36(51)46-31(40(55)56)19-25-10-7-6-8-11-25/h6-8,10-11,13-16,21-24,29-34,49H,5,9,12,17-20,41H2,1-4H3,(H,42,43)(H,44,52)(H,45,53)(H,46,51)(H,47,50)(H,55,56)/t24-,29-,30-,31-,32-,33-,34-/m0/s1

SMILES: CC[C@H](C)[C@@H](C(=N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=N[C@@H](Cc1ccccc1)C(=O)O)O)O)N=C([C@H](Cc1ccc(cc1)O)N=C([C@H](C(C)C)N)O)O

Synonyms:

• Angiotensin I/II (3-8)
• H-Val-Tyr-Ile-His-Pro-Phe-OH
• L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine

Angiotensin II (3-8), Human

CAS: 23025-68-5

For cellular and molecular biology applications

Color and Shape: Lyophilized powder, White

Ref: 02-J66457

Angiotensin I/II (3-8)

CAS: 23025-68-5

Ang IV, one of the major metabolites of angiotensin II, binds with high affinity to a new angiotensin binding site distinct and separate from angiotensin II receptors.

Formula: C₄₀H₅₄N₈O₈

Purity: 99.1%

Color and Shape: White Powder

Molecular weight: 774.92

Ref: 01-4018068

Angiotensin IV acetate

CAS: 23025-68-5

Angiotensin IV (Human) is a peptide hormone and peptidase inhibitor that belongs to the family of angiotensins. It is produced by the renin-angiotensin system and inhibits the action of angiotensin converting enzyme, an enzyme that converts angiotensin I into angiotensin II. Angiotensin IV has been used for research purposes as well as for therapeutic applications in cardiovascular diseases, hypertension, and congestive heart failure. Angiotensin IV is a high purity product with a purity greater than 99%.

Formula: C₄₀H₅₄N₈O₈

Purity: Min. 95%

Molecular weight: 774.91 g/mol

Ref: 3D-PAN-4331-V

Angiotensin IV acetate

CAS: 23025-68-5

Angiotensin IV (human) is an active analogue of the chemoattractant protein, angiotensin. It is a potent anti-inflammatory cytokine that inhibits the production of pro-inflammatory cytokines, such as IL-10. Angiotensin IV (human) has been shown to significantly reduce the production of pro-inflammatory cytokines in mice with chronic inflammation and can be used to treat autoimmune diseases. The biological properties of this protein have been studied using polymerase chain reactions and cytosolic calcium assays. It has been shown to inhibit binding to both the angiotensin receptor and angiotensin converting enzyme. Angiotensin IV (human) also has locomotor activity.

Formula: C₄₀H₅₄N₈O₈

Purity: Min. 95%

Molecular weight: 774.91 g/mol

Ref: 3D-PAN-4331

Angiotensin II (3-8), human

CAS: 23025-68-5

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₄₀H₅₄N₈O₈

Molecular weight: 774.9 g/mol

Ref: 3D-PP50266

Angiotensin I/II (3-8)

CAS: 23025-68-5

Angiotensin I/II (3-8) H-Val-Tyr-Ile-His-Pro-Phe-OH is a peptide that has physiological effects and is used as a drug. It is an active analogue of the peptide hormone angiotensin II, which regulates blood pressure and fluid volume. Angiotensin I/II (3-8) H-Val-Tyr-Ile-His-Pro-Phe-OH binds to angiotensin receptors and stimulates the release of calcium ions from cytosolic stores in cells, leading to increased muscle contractions and vasoconstriction. This drug may also have effects on dopamine levels in the brain, locomotor activity, and biochemical properties such as enzyme activity or protein binding.br>
Angiotensin I/II (3-8) H-Val-Tyr-Ile-His Pro Phe OH has been shown to reduce the level of dopamine

Formula: C₄₀H₅₄N₈O₈

Purity: Min. 95%

Molecular weight: 774.91 g/mol

Ref: 3D-FA110283