4'-C-Methyl-2-thiouridine is a modified nucleoside that features a methyl group at the 4' position of the ribose sugar and a thiol group at the 2' position of the uracil base. This compound is of interest in biochemical and pharmaceutical research due to its potential role in influencing RNA structure and function. The presence of the thiol group can enhance the stability of RNA molecules and may affect their interactions with proteins and other nucleic acids. Additionally, the methylation at the 4' position can impact the nucleoside's recognition by various enzymes, potentially altering its biological activity. 4'-C-Methyl-2-thiouridine is often studied for its implications in gene expression regulation and its potential therapeutic applications, particularly in the context of antiviral and anticancer strategies. Its unique structural features make it a valuable tool for investigating nucleic acid chemistry and the development of novel RNA-based therapeutics.

4'-C-Methyl-2-thiouridine

2305415-74-9: 4'-C-Methyl-2-thiouridine is a modified nucleoside that features a methyl group at the 4' position of the ribose sugar and a thiol group at the 2' position of the uracil base. This compound is of interest in biochemical and pharmaceutical research due to its potential role in influencing RNA structure and function. The presence of the thiol group can enhance the stability of RNA molecules and may affect their interactions with proteins and other nucleic acids. Additionally, the methylation at the 4' position can impact the nucleoside's recognition by various enzymes, potentially altering its biological activity. 4'-C-Methyl-2-thiouridine is often studied for its implications in gene expression regulation and its potential therapeutic applications, particularly in the context of antiviral and anticancer strategies. Its unique structural features make it a valuable tool for investigating nucleic acid chemistry and the development of novel RNA-based therapeutics.

Nucleoside Derivatives - 4’-Modified nucleosides; Thio-nucleosides

<p>4’-C-Methyl-2-thiouridine is an activator that has anticancer properties. It is a modified nucleoside with antiviral and antifungal activities, which has been shown to inhibit the growth of human tumor cells in vitro. 4’-C-methyl-2-thiouridine is able to inhibit viral replication in vitro and has been shown to be active against herpes simplex virus type 1 (HSV1) and herpes simplex virus type 2 (HSV2). Interestingly, this compound was found to have no effect on the intracellular levels of thymidine kinase or on cellular DNA synthesis.</p>

CAS 2305415-74-9

4'-C-Methyl-2-thiouridine

4'-C-Methyl-2-thiouridine

Ref: TM-TNU0406

4’-C-Methyl-2-thiouridine

Ref: 3D-NM163136