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CAS 23074-02-4

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3-cis-Hydroxyglibenclamide

Description:
3-cis-Hydroxyglibenclamide, with the CAS number 23074-02-4, is a derivative of glibenclamide, which is an antidiabetic medication used primarily in the management of type 2 diabetes mellitus. This compound features a hydroxy group (-OH) at the 3-cis position, which influences its pharmacological properties. It is characterized by its ability to stimulate insulin secretion from pancreatic beta cells, thereby lowering blood glucose levels. The presence of the hydroxy group may also affect its solubility and bioavailability compared to its parent compound. Typically, such derivatives are studied for their potential efficacy and safety profiles, as modifications can lead to variations in therapeutic effects and side effects. In terms of physical properties, like many sulfonylureas, it is expected to be a solid at room temperature, with specific melting and boiling points that would depend on its molecular structure. As with any pharmaceutical compound, its use should be guided by clinical evidence and regulatory approval.
Formula:C23H28ClN3O6S
InChI:InChI=1/C23H28ClN3O6S/c1-33-21-10-7-16(24)13-20(21)22(29)25-12-11-15-5-8-19(9-6-15)34(31,32)27-23(30)26-17-3-2-4-18(28)14-17/h5-10,13,17-18,28H,2-4,11-12,14H2,1H3,(H,25,29)(H2,26,27,30)/t17-,18+/s2
InChI key:InChIKey=VFBAJFAMXTVSQA-ZVOYONDMNA-N
SMILES:C(NCCC1=CC=C(S(NC(N[C@H]2C[C@@H](O)CCC2)=O)(=O)=O)C=C1)(=O)C3=C(OC)C=CC(Cl)=C3
Synonyms:
  • cis-3-Hydroxyglyburide
  • Benzamide, 5-chloro-N-[2-[4-[[[[[(1R,3S)-3-hydroxycyclohexyl]amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-, rel-
  • rel-5-Chloro-N-[2-[4-[[[[[(1R,3S)-3-hydroxycyclohexyl]amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide
  • Benzamide, 5-chloro-N-[2-[4-[[[[(3-hydroxycyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-, cis-
  • Urea, 1-[[p-[2-(5-chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-(3-hydroxycyclohexyl)-, cis-
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