CAS 231277-92-2

Lapatinib

Description:

Lapatinib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of breast cancer, particularly those that are HER2-positive. It functions by inhibiting the activity of the epidermal growth factor receptor (EGFR) and HER2, which are involved in the proliferation and survival of cancer cells. Lapatinib is typically administered orally and is often used in combination with other therapies, such as capecitabine, to enhance its efficacy. The compound has a molecular formula that reflects its complex structure, which includes multiple aromatic rings and functional groups that contribute to its pharmacological activity. Lapatinib is characterized by its moderate solubility in organic solvents and relatively low solubility in water, which can influence its bioavailability. Side effects may include diarrhea, rash, and potential cardiac issues, necessitating careful monitoring during treatment. Overall, Lapatinib represents a targeted therapeutic approach in oncology, exemplifying the shift towards personalized medicine in cancer treatment.

Formula: C₂₉H₂₆ClFN₄O₄S

InChI: InChI=1/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)

InChI key: InChIKey=BCFGMOOMADDAQU-UHFFFAOYSA-N

SMILES: N(C=1C2=C(C=CC(=C2)C=3OC(CNCCS(C)(=O)=O)=CC3)N=CN1)C4=CC(Cl)=C(OCC5=CC(F)=CC=C5)C=C4

Synonyms:

• 4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-
• 4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline
• Gd 2016
• Gsk 572016
• Gw 572016
• Gw 572016X
• Lapatinib base
• N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-[5-[[[2-(methanesulfonyl)ethyl]amino]methyl]-2-furyl]-4-quinazolinamine
• N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furyl]-4-quinazolinamine
• N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine
• N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
• N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-Quinazolinamine
• N-[4-(3-Fluorobenzyloxy)-3-chlorophenyl]-6-[5-[[2-(methylsulfonyl)ethylamino]methyl]furan-2-yl]quinazolin-4-amine
• N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine
• Tycerb
• Tyverb
• Lapatinib

Lapatinib

CAS: 231277-92-2

Formula: C₂₉H₂₆ClFN₄O₄S

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 581.06

Ref: 3B-L0360

N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine

CAS: 231277-92-2

Formula: C₂₉H₂₆ClFN₄O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 581.0575

Ref: IN-DA0039KT

Lapatinib

CAS: 231277-92-2

Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity.

Formula: C₂₉H₂₆ClFN₄O₄S

Purity: 99.00% - 99.81%

Color and Shape: Powder

Molecular weight: 581.06

Ref: TM-T0078

Lapatinib

CAS: 231277-92-2

Formula: C₂₉H₂₆ClFN₄O₄S

Purity: ≥ 99.0%

Color and Shape: Pale yellow to yellow powder

Molecular weight: 581.06

Ref: 7W-GP6924

Lapatinib

CAS: 231277-92-2

Lapatinib

Purity: ≥98%

Molecular weight: 581.06g/mol

Ref: 54-BUP16996

Lapatinib

CAS: 231277-92-2

Formula: C₂₉H₂₆ClFN₄O₄S

Color and Shape: Yellow Solid

Molecular weight: 581.06

Ref: 4Z-L-251

Lapatinib

CAS: 231277-92-2

Lapatinib

Purity: 98%

Molecular weight: 581.06g/mol

Ref: 54-PC108772

Lapatinib

Controlled Product

CAS: 231277-92-2

Applications Lapatinib is a selective inhibitor of epidermal growth factor receptor (EGFR) and HER-2 tyrosine kinases. This drug is used to treat breast cancer, especially metastatic breast cancer that has progressed after trastuzumab treatment and other chemotherapy.
References Konecny, G., et al.: Cancer Res., 66, 1630 (2006); Geyer, C., et al.: N. Engl. J. Med., 355, 2733 (2006);

Formula: C₂₉H₂₆ClFN₄O₄S

Color and Shape: Light Yellow

Molecular weight: 581.06

Ref: TR-L175808

Lapatinib

CAS: 231277-92-2

Inhibitor of EGFR (ErbB1) and HER2 (ErbB2) receptor tyrosine kinases. Used for sensitization of HER2-overexpressing cancer cells to radiation as well as chemotherapy to tamoxifen- and trastuzumab-resistant cell lines. The compound blocks signalling via Akt and mitogen-activated protein kinase (MAPK) pathways leading to reduced cell survival. In trastuzumab resistant cancer cells, it inhibits HER2 phosphorylation, prevents receptor ubiquitination and causes accumulation of inactive HER2 dimers on the cell surface.

Formula: C₂₉H₂₆ClFN₄O₄S

Purity: Min. 95%

Color and Shape: Slightly Yellow Powder

Molecular weight: 581.06 g/mol

Ref: 3D-FC12433

Lapatinib base - Bio-X ™

CAS: 231277-92-2

Lapatinib is an antineoplastic agent used to treat breast and lung cancer. This drug is also a tyrosine kinase inhibitor and inhibits human epidermal growth factor receptor type 2 (HER2/ERBB2) and epidermal growth factor receptor (HER1/EGFR/ERBB1). Lapatinib has shown to inhibit ERBB-driven tumor cell growth in vitro and in various animal models.

Formula: C₂₉H₂₆ClFN₄O₄S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 581.06 g/mol

Ref: 3D-BC164610

Lapatinib ditosylate monohydrate

CAS: 231277-92-2

Inhibitor of EGFR (ErbB1) and HER2 (ErbB2) receptor tyrosine kinases. Used for sensitization of HER2-overexpressing cancer cells to radiation as well as chemotherapy to tamoxifen- and trastuzumab-resistant cell lines. The compound blocks signalling via Akt and mitogen-activated protein kinase (MAPK) pathways leading to reduced cell survival. In trastuzumab resistant cancer cells, it inhibits HER2 phosphorylation, prevents receptor ubiquitination and causes accumulation of inactive HER2 dimers on the cell surface.

Formula: C₂₉H₂₆ClFN₄O₄S•(C₇H₈O₃S)₂•H₂O

Purity: Min. 95%

Molecular weight: 943.48 g/mol

Ref: 3D-FL24843