CAS 231277-92-2: Lapatinib
Description:Lapatinib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of breast cancer, particularly those that are HER2-positive. It functions by inhibiting the activity of the epidermal growth factor receptor (EGFR) and HER2, which are involved in the proliferation and survival of cancer cells. Lapatinib is typically administered orally and is often used in combination with other therapies, such as capecitabine, to enhance its efficacy. The compound has a molecular formula that reflects its complex structure, which includes multiple aromatic rings and functional groups that contribute to its pharmacological activity. Lapatinib is characterized by its moderate solubility in organic solvents and relatively low solubility in water, which can influence its bioavailability. Side effects may include diarrhea, rash, and potential cardiac issues, necessitating careful monitoring during treatment. Overall, Lapatinib represents a targeted therapeutic approach in oncology, exemplifying the shift towards personalized medicine in cancer treatment.
Formula:C29H26ClFN4O4S
InChI:InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)
InChI key:InChIKey=BCFGMOOMADDAQU-UHFFFAOYSA-N
SMILES:O=S(=O)(C)CCNCC=1OC(=CC1)C=2C=CC3=NC=NC(NC4=CC=C(OCC=5C=CC=C(F)C5)C(Cl)=C4)=C3C2
- Synonyms:
- 4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-
- 4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline
- Gd 2016
- Gsk 572016
- Gw 572016
- Gw 572016X
- Lapatinib base
- N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-[5-[[[2-(methanesulfonyl)ethyl]amino]methyl]-2-furyl]-4-quinazolinamine
- N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furyl]-4-quinazolinamine
- N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine
- See more synonyms
- N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
- N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-Quinazolinamine
- N-[4-(3-Fluorobenzyloxy)-3-chlorophenyl]-6-[5-[[2-(methylsulfonyl)ethylamino]methyl]furan-2-yl]quinazolin-4-amine
- N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine
- Tycerb
- Tyverb
- Lapatinib
![N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-fur…](https://static.cymitquimica.com/products/IN/thumb/DA0039KT.jpg)
