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CAS 23155-00-2

:

4-trans-Hydroxyglibenclamide

Description:
4-trans-Hydroxyglibenclamide, with the CAS number 23155-00-2, is a derivative of glibenclamide, which is an antidiabetic medication used primarily in the management of type 2 diabetes mellitus. This compound features a hydroxy group at the 4-position of the aromatic ring, which influences its pharmacological properties. It is characterized by its ability to stimulate insulin secretion from pancreatic beta cells, thereby lowering blood glucose levels. The presence of the hydroxy group may also affect its solubility and bioavailability compared to its parent compound. Typically, such derivatives are studied for their potential therapeutic benefits and side effects. In terms of physical properties, 4-trans-Hydroxyglibenclamide is expected to be a solid at room temperature, with specific melting and boiling points that would need to be determined experimentally. Its chemical structure includes functional groups that may participate in hydrogen bonding, influencing its interactions with biological targets. As with many pharmaceutical compounds, safety and efficacy are critical, necessitating thorough research and clinical evaluation.
Formula:C23H28ClN3O6S
InChI:InChI=1/C23H28ClN3O6S/c1-33-21-11-4-16(24)14-20(21)22(29)25-13-12-15-2-9-19(10-3-15)34(31,32)27-23(30)26-17-5-7-18(28)8-6-17/h2-4,9-11,14,17-18,28H,5-8,12-13H2,1H3,(H,25,29)(H2,26,27,30)/t17-,18-
InChI key:InChIKey=IUWSGCQEWOOQDN-IYARVYRRNA-N
SMILES:C(NCCC1=CC=C(S(NC(N[C@H]2CC[C@H](O)CC2)=O)(=O)=O)C=C1)(=O)C3=C(OC)C=CC(Cl)=C3
Synonyms:
  • 4-trans-Hydroxycyclohexyl glyburide
  • 4-trans-Hydroxyglibenclamide
  • 5-Chloro-N-[2-[4-[[[[(trans-4-hydroxycyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide
  • Benzamide,5-chloro-N-[2-[4-[[[[(4-hydroxycyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-,trans-
  • N-[4-[b-(2-Methoxy-5-chlorobenzamido)ethyl]benzenesulfonyl]-N'-(trans-4-hydroxycyclohexyl)urea
  • Urea, 1-[[p-[2-(5-chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-(4-hydroxycyclohexyl)-, trans-
  • Urea,1-[[p-[2-(5-chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-(4-hydroxycyclohexyl)-,trans- (8CI)
  • trans-4-Hydroxyglyburide
  • trans-N-4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenylsulfonyl-N'-(4-hydroxycyclohexyl)urea
  • Benzamide, 5-chloro-N-[2-[4-[[[[(trans-4-hydroxycyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-
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Found 3 products.
  • rac-trans-4-hydroxy Glyburide
    Targetmol
    + Info

    rac-trans-4-hydroxy Glyburide

    CAS:
    rac-trans-4-hydroxy Glyburide, a metabolite of glyburide, inhibits binding at SUR1/Kir6.2 sites with IC50 values of 0.95 and 100 nM.
    Formula:C23H28ClN3O6S
    Color and Shape:Solid
    Molecular weight:510.0

    Ref: TM-T35635

    1mg
    274.00€
  • 4-trans-Hydroxyglibenclamide
    Glentham
    + Info

    4-trans-Hydroxyglibenclamide

    CAS:

    Ref: 7W-GW4968

    1mg
    236.00€
    5mg
    851.00€
  • rac trans-4-Hydroxy Glyburide
    TRC
    + Info

    rac trans-4-Hydroxy Glyburide

    Controlled Product
    CAS:

    Stability Hygroscopic and Moisture Sensitive
    Applications rac trans-4-Hydroxy Glyburide is a metabolite of Glyburide which is used as an antidiabetic.
    References Heptner, W., et al.: Pharmaceut. Res., 5, 215 (1984), Rydberg, T., et al.: Br. J. Clin. Pharm., 43, 373 (1997),

    Formula:C23H28ClN3O6S
    Color and Shape:Neat
    Molecular weight:510.00

    Ref: TR-H942625

    1mg
    197.00€
    25mg
    2,521.00€
    2500µg
    370.00€