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CAS 23155-02-4

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Fosfomycin

Description:
Fosfomycin, with the CAS number 23155-02-4, is an antibiotic that is primarily used to treat urinary tract infections caused by susceptible bacteria. It is a phosphonic acid derivative and functions by inhibiting bacterial cell wall synthesis, specifically targeting the enzyme MurA, which is crucial for peptidoglycan formation. Fosfomycin is effective against a broad spectrum of Gram-positive and Gram-negative bacteria, including some strains resistant to other antibiotics. It is typically administered as a prodrug, fosfomycin trometamol, which enhances its solubility and bioavailability. The substance is characterized by its low toxicity profile, making it suitable for use in various patient populations, including those with renal impairment, although dosage adjustments may be necessary. Fosfomycin is usually given orally or intravenously, depending on the severity of the infection. Its unique mechanism of action and resistance to beta-lactamase enzymes make it a valuable option in the treatment of multidrug-resistant infections.
Formula:C3H7O4P
InChI:InChI=1S/C3H7O4P/c1-2-3(7-2)8(4,5)6/h2-3H,1H3,(H2,4,5,6)/t2-,3+/m0/s1
InChI key:InChIKey=YMDXZJFXQJVXBF-STHAYSLISA-N
SMILES:P(=O)(O)(O)[C@@H]1[C@H](C)O1
Synonyms:
  • (-)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid
  • (-)-(cis-1,2-Epoxypropyl)phosphonic acid
  • (-)-Phosphonomycin
  • (2R-cis)-(3-Methyloxiranyl)phosphonic acid
  • Antibiotic 833A
  • Fosfocina
  • Fosfomicin
  • Fosfomicina
  • Fosfomycin
  • Fosfomycine
  • See more synonyms
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