CAS 23180-57-6

Paeoniflorin

Description:

Paeoniflorin is a natural compound primarily extracted from the roots of the peony plant, particularly Paeonia lactiflora. It is classified as a monoterpene glycoside and is known for its various pharmacological properties. Paeoniflorin exhibits anti-inflammatory, analgesic, and neuroprotective effects, making it of interest in traditional medicine and modern pharmacology. The compound is often studied for its potential therapeutic applications in conditions such as pain, anxiety, and neurodegenerative diseases. In terms of its chemical structure, Paeoniflorin consists of a glucose moiety linked to a phenolic compound, which contributes to its biological activity. It is typically soluble in water and exhibits stability under various pH conditions. Additionally, Paeoniflorin has been shown to modulate various signaling pathways, enhancing its potential as a therapeutic agent. Its safety profile is generally favorable, but further research is necessary to fully understand its mechanisms of action and potential side effects.

Formula: C₂₃H₂₈O₁₁

InChI: InChI=1S/C23H28O11/c1-20-9-22(29)13-7-23(20,32-18-16(27)15(26)14(25)12(8-24)31-18)21(13,19(33-20)34-22)10-30-17(28)11-5-3-2-4-6-11/h2-6,12-16,18-19,24-27,29H,7-10H2,1H3/t12-,13-,14-,15+,16-,18+,19-,20+,21+,22-,23+/m1/s1

InChI key: InChIKey=YKRGDOXKVOZESV-WRJNSLSBSA-N

SMILES: C(OC(=O)C1=CC=CC=C1)[C@@]23[C@@]4(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@@]6(C)O[C@@]2(O[C@@](O)([C@@]3(C4)[H])C6)[H]

Synonyms:

• (1aR,2S,3aR,5R,5aR,5bS)-5b-[(Benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl β-<span class="text-smallcaps">D</span>-glucopyranoside
• 2,5-Methano-1H-3,4-dioxacyclobuta[cd]pentalene, β-<span class="text-smallcaps">D</span>-glucopyranoside deriv.
• Nsc 178886
• Paeoniflorin
• Peoniflorin
• β-<span class="text-smallcaps">D</span>-Glucopyranoside, (1aR,2S,3aR,5R,5aR,5bS)-5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl
• β-<span class="text-smallcaps">D</span>-Glucopyranoside, 5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl, [1aR-(1aα,2β,3aα,5α,5aα,5bα)]-
• β-D-Glucopyranosid, 5b-[(Benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl, [1aR-(1aα,2β,3aα,5α,5aα,5ba)]-
• β-D-Glucopyranoside, 5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl, [1aR-(1aα,2β,3aα,5α,5aα,5bα)]-
• β-D-glucopiranosido, 5b-[(benzoiloxi)metil]tetrahidro-5-hidroxi-2-metil-2,5-metano-1H-3,4-dioxaciclobuta[cd]pentalen-1a(2H)-il, [1aR-(1aα,2β,3aα,5α,5aα,5bα)]-
• β-D-glucopyrannoside, [(benzoyloxy)methyl]-5b tetrahydrohydroxy-5 methyl-2 methano-2,5 1H-dioxacyclo-3,4 buta[cd]pentalenyl 1a(2H), [1aR-(1aα,2β,3aα,5α,5aα,5bα)]-
• Paeoniflorm
• (1aR,2S,3aR,5R,5aR,5bS)-5b-[(Benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl β-D-glucopyranoside
• [(3S,3aR,6S,7aR)-3-(beta-D-glucopyranosyloxy)-7a-hydroxy-6-methyloctahydro-2,6-epoxy-1-benzofuran-3-yl]methyl benzoate
• Reishi Mushroom
• [(1aR,2R,3aR,5S,5aR,5bS)-1a-(beta-D-glucopyranosyloxy)-5-hydroxy-2-methyltetrahydro-1H-2,5-methano-3,4-dioxacyclobuta[cd]pentalen-5b(3aH)-yl]methyl benzoate
• [1a-(hexopyranosyloxy)-5-hydroxy-2-methyltetrahydro-1H-2,5-methano-3,4-dioxacyclobuta[cd]pentalen-5b(3aH)-yl]methyl benzoate
• [(1aR,2S,3aR,5R,5aR)-1a-(beta-D-glucopyranosyloxy)-5-hydroxy-2-methyltetrahydro-1H-2,5-methano-3,4-dioxacyclobuta[cd]pentalen-5b(3aH)-yl]methyl benzoate
• 2,5-Methano-1H-3,4-dioxacyclobuta[cd]pentalene, β-D-glucopyranoside deriv.
• Reishi Mushroom Extract
• [(1aR,2S,3aR,5R,5aR,5bS)-1a-(beta-D-glucopyranosyloxy)-5-hydroxy-2-methyltetrahydro-1H-2,5-methano-3,4-dioxacyclobuta[cd]pentalen-5b(3aH)-yl]methyl benzoate

Paeoniflorin

CAS: 23180-57-6

Formula: C₂₃H₂₈O₁₁

Purity: >95.0%(NMR)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 480.47

Ref: 3B-P1876

PAEONIFLORIN CRS

CAS: 23180-57-6

PAEONIFLORIN CRS

Formula: C₂₃H₂₈O₁₁

Molecular weight: 480.4618

Ref: 41-Y0001856

Paeoniflorin

CAS: 23180-57-6

Other glycosides, natural or reproduced by synthesis, and their salts, ethers, esters and other derivatives

Formula: C₂₃H₂₈O₁₁

Color and Shape: Off-White White Powder

Molecular weight: 480.16316

Ref: 45-1491616

Paeoniflorin

CAS: 23180-57-6

Paeoniflorin

Purity: ≥95%

Molecular weight: 480.46g/mol

Ref: 54-BUP15107

Paeoniflorin

CAS: 23180-57-6

Paeoniflorin

Purity: 98%

Molecular weight: 480.46g/mol

Ref: 54-OR1027748

Paeoniflorin

CAS: 23180-57-6

Paeoniflorin, a novel heat shock protein-inducing compound, is mediated by the activation of heat shock transcription factor 1 (HSF1), which has antiallergic, anti-obesity, anti-inflammatory and immunoregulatory effects. Paeoniflorin can activate PI3K/Akt signaling pathway to protect the PC12 cell injury induced by Aβ25-35, it protects thymocytes against irradiation-induced cell damage by scavenging ROS and attenuating the activation of the mitogen-activated protein kinases.

Formula: C₂₃H₂₈O₁₁

Purity: 95%~99%

Molecular weight: 480.466

Ref: BP-BP1056

Paeoniflorin

CAS: 23180-57-6

Formula: C₂₃H₂₈O₁₁

Molecular weight: 480.47

Ref: 4Z-P-311001

Paeoniflorin

CAS: 23180-57-6

Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.

Formula: C₂₃H₂₈O₁₁

Purity: 96.9% - 97.43%

Color and Shape: White Fine Powder

Molecular weight: 480.46

Ref: TM-T2230

Paeoniflorin

CAS: 23180-57-6

Formula: C₂₃H₂₈O₁₁

Purity: ≥ 97.5%

Color and Shape: White powder

Molecular weight: 480.46

Ref: 7W-GC2063

Paeoniflorin RS

CAS: 23180-57-6

Color and Shape: White Solid Powder

Ref: 2K-1144000021

Paeoniflorin

CAS: 23180-57-6

Natural glycoside

Formula: C₂₃H₂₈O₁₁

Purity: ≥ 90.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 480.47

Ref: 5G-89384

Paeoniflorin (>80%)

Controlled Product

CAS: 23180-57-6

Applications Paeoniflorin is an active compound of the Paeonia root. Paeoniflorin inhibits Aβ25-35-induced mitochondrial dysfunction, which includes decreased mitochondrial membrane potential, increased Bax/Bcl-2 ratio, cytochrome c release and activity of caspase-3 and caspase-9. Paeoniflorin could attenuate or restore the viability loss, apoptotic increase, and ROS production induced by Aβ25-35 in SH-SY5Y cells.
References Yuan,Y., et. al.: Int. J. Mol. Sci., 14, 18502 (2013); Wang, K., et. al.: Cell Mol. Neurobiol., 34, 227 (2014)

Formula: C₂₃H₂₈O₁₁

Purity: >80%

Color and Shape: Neat

Molecular weight: 480.46

Ref: TR-P133830

Paeoniflorin

CAS: 23180-57-6

Paeoniflorin is a bioactive compound, which is a monoterpene glycoside derived from the roots of Paeonia lactiflora, commonly known as peony. This compound functions through multiple mechanisms, including the modulation of calcium channels, the inhibition of the production of pro-inflammatory cytokines, and the regulation of neurotransmitter levels. It effectively exhibits anti-inflammatory and immunomodulatory effects.

Formula: C₂₃H₂₈O₁₁

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 480.46 g/mol

Ref: 3D-MP08290

PAEONIFLORIN

CAS: 23180-57-6

Purity: 95%

Molecular weight: 480.4660034

Ref: 10-F859163

b-D-Glucopyranoside,(1aR,2S,3aR,5R,5aR,5bS)-5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl

CAS: 23180-57-6

Formula: C₂₃H₂₈O₁₁

Purity: 95%

Color and Shape: Solid

Molecular weight: 480.4618

Ref: IN-DA00I4J3

Paeoniflorin

CAS: 23180-57-6

Paeoniflorin

Formula: C₂₃H₂₈O₁₁

Purity: 88.6%

Color and Shape: Off-White

Molecular weight: 480.16316

Ref: 47-769