CAS 231957-27-0

Guanosine,N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-

Description:

Guanosine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]- is a synthetic compound that belongs to the class of nucleosides, which are essential building blocks of nucleic acids. This particular compound features a guanosine backbone, modified with an N-acetyl group and a complex substituent at the 5' position, which includes a bis(4-methoxyphenyl)phenylmethyl moiety. The presence of methoxy groups enhances its lipophilicity and may influence its biological activity. The compound is likely to exhibit properties typical of nucleosides, such as potential roles in cellular signaling or as precursors in biochemical pathways. Its structural modifications suggest that it may have applications in medicinal chemistry, particularly in the development of antiviral or anticancer agents. The specific interactions and biological effects would depend on its conformation and the presence of functional groups, which could affect binding to nucleic acid targets or enzymes. Further studies would be necessary to elucidate its full pharmacological profile and potential therapeutic uses.

Formula: C₃₃H₃₃N₅O₈

Synonyms:

• N-ACETYL-5’-DMT GUANOSINE
• N-[9-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]-6-oxo-3H-purin-2-yl]acetamide
• Guanosine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-
• N2-acetyl-5'-O-(4,4'-dimethoxytrityl)guanosine

N2-Acetyl-5'-O-DMT-guanosine

CAS: 231957-27-0

N2-Acetyl-5'-O-DMT-guanosine is a novel anticancer nucleoside that has been synthesized to mimic the natural nucleotides found in DNA. It is phosphorylated to N2-acetyl-5'-O-DMT-guanosine monophosphate, which can be converted back to the active form of N2-acetyl-5'-O-DMT guanosine by phosphatases. This agent activates DNA synthesis and inhibits viral replication, including HIV and herpes simplex virus. The antiviral activity is due to its inhibition of viral DNA polymerase and diphosphate kinase.

Purity: Min. 95%

Ref: 3D-NA138797