CAS 23197-98-0

1-bromoguanosine 5'-(tetrahydrogen triphosphate)

Description:

1-Bromoguanosine 5'-(tetrahydrogen triphosphate), with the CAS number 23197-98-0, is a nucleotide analog that plays a significant role in biochemical research, particularly in studies involving nucleic acid metabolism and enzyme interactions. This compound features a guanosine base, which is a purine nucleoside, linked to a triphosphate group, making it a key component in energy transfer and signaling within cells. The presence of the bromine atom at the 1-position of the guanosine structure can influence its reactivity and interactions with various biological molecules, such as enzymes and receptors. The tetrahydrogen triphosphate moiety is crucial for its function, as it can participate in phosphorylation reactions. This compound is often used in experimental settings to investigate the mechanisms of nucleotide incorporation and the effects of halogen substitutions on nucleic acid behavior. Its unique structural characteristics make it a valuable tool in molecular biology and biochemistry, aiding in the understanding of cellular processes and the development of therapeutic agents.

Formula: C₁₀H₂₁BrN₅O₁₇P₃

InChI: InChI=1/C10H12BrN5O5.3H3O4P/c11-9-13-3-6(14-10(12)15-7(3)20)16(9)8-5(19)4(18)2(1-17)21-8;3*1-5(2,3)4/h2,4-5,8,17-19H,1H2,(H3,12,14,15,20);3*(H3,1,2,3,4)/t2-,4-,5-,8-;;;/m1.../s1

SMILES: C([C@@H]1[C@H]([C@H]([C@H](n2c3c(c(nc(=N)[nH]3)O)nc2Br)O1)O)O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O

Synonyms:

• 8-Bromoguanosine phosphate (1:3)
• Guanosine, 8-Bromo-, Phosphate (1:3)
• 8-Bromoguanosine Tris(Phosphate)

8-Br-GTP

CAS: 23197-98-0

8-Br-GTP, a GTP analog, inhibits FtsZ polymerization/GTPase (K i 31.8 μM), aids nucleic acid modification.

Formula: C₁₀H₁₅BrN₅O₁₄P₃

Color and Shape: Solid

Molecular weight: 602.076

Ref: TM-T39857

8-Bromoguanosine-5'-triphosphate sodium salt - 10 mM aqueous solution

CAS: 23197-98-0

8-Bromoguanosine-5'-triphosphate sodium salt is a nucleotide analog that inhibits the enzyme ribonucleotide reductase. This drug inhibits bacterial growth by interfering with protein synthesis and cell division. It binds to the purine riboswitch, which is an allosteric regulatory binding site on the ribosome, inactivating it. 8-Bromoguanosine-5'-triphosphate sodium salt also binds to the active site of bacterial RNA polymerase and inhibits DNA synthesis. The activity of this drug has been shown using a bacteriophage system in which the enzyme protein synthesis was inhibited by 8-bromoguanosine-5'-triphosphate sodium salt.

Formula: C₁₀H₁₅N₅O₁₄P₃Br·xNa

Purity: Min. 95%

Molecular weight: 602.08 g/mol

Ref: 3D-NB143914