CAS 23205-42-7

3-Deazauridine

Description:

3-Deazauridine is a nucleoside analog that is structurally related to uridine, where the nitrogen atom at the 3-position of the uracil base is replaced by a carbon atom. This modification alters its biological activity and can influence its interaction with nucleic acid synthesis. The compound is known for its potential antiviral and anticancer properties, as it can inhibit the replication of certain viruses and interfere with cellular processes. 3-Deazauridine is often studied for its effects on RNA metabolism and its ability to act as a substrate for various enzymes involved in nucleic acid synthesis. Its mechanism of action typically involves incorporation into RNA, leading to the disruption of normal RNA function. The substance is also characterized by its solubility in water and its stability under physiological conditions, making it a subject of interest in medicinal chemistry and pharmacology. As with many nucleoside analogs, further research is ongoing to fully elucidate its therapeutic potential and mechanisms of action.

Formula: C₁₀H₁₃NO₆

InChI: InChI=1/C10H13NO6/c12-4-6-8(15)9(16)10(17-6)11-2-1-5(13)3-7(11)14/h1-3,6,8-10,12-13,15-16H,4H2/t6-,8-,9-,10-/m1/s1

InChI key: InChIKey=CBOKZNLSFMZJJA-PEBGCTIMSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)C=C(O)C=C2

Synonyms:

• 1-beta-D-ribofuranosylpyridine-2,4(1H,3H)-dione
• 1-β-<span class="text-smallcaps">D</span>-Ribofuranosyl-4-hydroxy-2-pyridone
• 2(1H)-Pyridinone, 4-hydroxy-1-beta-D-ribofuranosyl- (9CI)
• 2(1H)-Pyridinone, 4-hydroxy-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 2(1H)-Pyridone, 4-hydroxy-1-beta-D-ribofuranosyl-
• 2(1H)-Pyridone, 4-hydroxy-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 2-hydroxy-1-(beta-D-ribofuranosyl)pyridin-4(1H)-one
• 3-Deazuridine
• 4-Hydroxy-1-(β-<span class="text-smallcaps">D</span>-ribofuranosyl)-2-pyridone
• 4-Hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridinone
• 4-Hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridone
• 4-Hydroxy-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-2(1H)-pyridinone
• 4-hydroxy-1-(beta-D-ribofuranosyl)pyridin-2(1H)-one
• Nsc 126849
• 2(1H)-Pyridinone, 4-hydroxy-1-β-D-ribofuranosyl-
• 4-Hydroxy-1-(β-D-ribofuranosyl)-2-pyridone
• 3-Deazauridine
• 4-Hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridinone
• 2(1H)-Pyridone, 4-hydroxy-1-β-D-ribofuranosyl-
• 4-Hydroxy-1-(beta-D-ribofuranosyl)-2-pyridone
• 3-DEAZAURIDINE CRYSTALLINE
• 4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyridinon
• 4-Hydroxy-1-(β-D-ribofuranosyl)-1,2-dihydropyridin-2-one
• 4-Hydroxy-1-β-D-ribofuranosyl-2(1H)pyridone
• 4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyridon
• 3-Deazauridine, 4-Hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridinone, 3-DAU, NSC 126849
• 1-β-D-Ribofuranosyl-4-hydroxy-2-pyridone

2(1H)-Pyridinone, 4-hydroxy-1-β-D-ribofuranosyl-

CAS: 23205-42-7

Formula: C₁₀H₁₃NO₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 243.2133

Ref: IN-DA002MIL

3-Deazauridine

CAS: 23205-42-7

Formula: C₁₀H₁₃NO₆

Purity: ≥ 95.0%

Color and Shape: White or off-white powder

Molecular weight: 243.21

Ref: 7W-GN7782

3-Deazauridine

CAS: 23205-42-7

3-Deazauridine

Purity: ≥98%

Molecular weight: 243.21g/mol

Ref: 54-BUP13874

3-Deazauridine

CAS: 23205-42-7

3-Deazauridine (NSC-126849), a uridine analog, blocks CTP synthesis by competing with CTP synthetase.

Formula: C₁₀H₁₃NO₆

Purity: 99.86%

Color and Shape: Solid

Molecular weight: 243.21

Ref: TM-T36866

3-Deazauridine

Controlled Product

CAS: 23205-42-7

Applications Antimetabolite antiviral dosing regimen for hepatitis C virus or flaviviridae therapy.
References Teh, A.-H., et al.: Biochemistry, 45, 7825 (2006),

Formula: C₁₀H₁₃NO₆

Color and Shape: Neat

Molecular weight: 243.21

Ref: TR-D203240

3-Deazauridine

CAS: 23205-42-7

3-Deazauridine is a uridine analog that inhibits the synthesis of DNA, RNA, and protein. It has been shown to inhibit the activity of 3-deazauridine synthetase in HL-60 cells. 3-Deazauridine also has significant cytotoxicity against colorectal adenocarcinoma cells and synergistic effects when used with other chemotherapeutic agents. The mechanism of action of 3-deazauridine is similar to that of other enzyme inhibitors, such as glycosidic bond formation or competitive inhibition. The sample preparation for this drug is complicated by its insolubility in water.

Formula: C₁₀H₁₃NO₆

Purity: Min. 97 Area-%

Color and Shape: White Powder

Molecular weight: 243.21 g/mol

Ref: 3D-ND16524

3-DEAZAURIDINE

CAS: 23205-42-7

Purity: 98%

Molecular weight: 243.21

Ref: 10-F803536