CAS 23214-92-8: Doxorubicin

Description:Doxorubicin, also known by its brand name Adriamycin, is an anthracycline antibiotic used primarily in cancer chemotherapy. It is derived from the bacterium Streptomyces peucetius and is characterized by its red color, which is indicative of its anthracycline structure. The chemical formula of doxorubicin is C27H29NO11, and it has a molecular weight of approximately 579.65 g/mol. Doxorubicin functions by intercalating into DNA, disrupting the replication process, and inhibiting topoisomerase II, which ultimately leads to apoptosis in rapidly dividing cancer cells. Its therapeutic applications include the treatment of various cancers, such as breast cancer, leukemia, and lymphoma. However, doxorubicin is associated with significant side effects, including cardiotoxicity, which limits its cumulative dose. It is typically administered intravenously and is often used in combination with other chemotherapeutic agents to enhance efficacy. Due to its potent effects and potential toxicity, careful monitoring during treatment is essential.

Formula:C₂₇H₂₉NO₁₁

InChI:InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1

InChI key:InChIKey=AOJJSUZBOXZQNB-TZSSRYMLSA-N

SMILES:O=C1C=2C=CC=C(OC)C2C(=O)C=3C(O)=C4C(=C(O)C13)CC(O)(C(=O)CO)CC4OC5OC(C)C(O)C(N)C5

Synonyms:
(1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside
(7S,9S)-7-[(2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,1 1-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
(8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
(8S-cis)-10-(3-Amino-2,3,6-Trideoxy-alpha-L-Lyxo-Hexopyranosyl)Oxy-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-Methoxy-5,12-Naphthacenedione
10-((3-Amino-2,3,6-trideoxy-alpha-L-lyso-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
14-Hydroxydaunomycin
5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, (8S,10S)-
5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S,10S)-
5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-
5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, (8S,10S)-
See more synonyms
5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S,10S)-
5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-
Adiblastine (Hydrochloride Salt)
Adriablastine (Hydrochloride Salt)
Adriablatina (Hydrochloride Salt)
Adriacin
Adriacin (hydrochloride salt)
Adriamycin PFS
Adriamycin PFS (hydrochloride salt)
Adriamycin RDF
Adriamycin RDF (hydrochloride salt)
Adriblastin
Adriblastina
Adriblastina (hydrochloride salt)
Adriblatina (Hydrochloride Salt)
Ameisu
Biotransdox
Caelix
Caelyx
Doxil
Doxorrubicina
Doxorubicin
Doxorubicin hydrochloride (hydrochloride salt)
Doxorubicine
Evacet
Farmablastina (hydrochloride salt)
Hydroxydaunomycin
Hydroxydaunomycin hydrochloride (hydrochloride salt)
Hydroxydaunorubicin
Hydroxydaunorubicin hydrochloride (hydrochloride salt)
Liporubicin
Livatag
Nsc 123127
Oncodox
Pk 2
Rubex
Rubex (hydrochloride salt)
Rubidox
(8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

Found 5 products.

Product data	Purity	Price range	Estimated delivery
Doxorubicin Hydrochloride REF: 3B-D4193CAS: 23214-92-8 25316-40-9	>95.0%(HPLC)	69.00 €~200.00 €	Tue 29 Apr 25
5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, (8S,10S)- REF: IN-DA00393DCAS: 23214-92-8	97%	To inquire	Tue 06 May 25
Doxorubicin Free Base REF: 54-BIFK0017CAS: 23214-92-8	- - -	247.00 €~2,754.00 €	Mon 05 May 25
Doxorubicin, free base REF: 7W-GA8306CAS: 23214-92-8	(HPLC) 98.0 - 102.0 % (anhydrous basis)	To inquire	Mon 05 May 25
Doxorubicin REF: TM-T1456CAS: 23214-92-8	98%	To inquire	Mon 05 May 25