CAS 23235-01-0

L-C-propargylglycine

Description:

L-C-propargylglycine, also known as L-α-amino-β-propargylglycine, is an amino acid derivative characterized by the presence of a propargyl group attached to the β-carbon of the glycine structure. Its chemical formula is C4H7NO2S, and it features a thiol group, which contributes to its reactivity and potential biological activity. This compound is known for its role as an inhibitor of the enzyme cystathionine γ-lyase, which is involved in the transsulfuration pathway, affecting the metabolism of sulfur-containing amino acids. L-C-propargylglycine has garnered interest in research for its potential implications in various physiological processes, including the modulation of hydrogen sulfide production in biological systems. The substance is typically a white to off-white solid and is soluble in water, making it suitable for various biochemical applications. Its unique structure and properties make it a valuable compound in both pharmaceutical research and biochemical studies, particularly in the context of metabolic regulation and neuroprotection.

Formula: C₅H₇NO₂

InChI: InChI=1/C5H7NO2/c1-2-3-4(6)5(7)8/h1,4H,3,6H2,(H,7,8)/t4-/m0/s1

SMILES: C#CC[C@@H](C(=O)O)N

Synonyms:

• H-Pra-OH
• 4-Pentynoic acid, 2-amino-, (2S)-
• 2-Aminopent-4-Ynoic Acid
• (2S)-2-aminopent-4-ynoic acid
• L-Propargylglycine
• S-2-Amino-4-Pentynoic acid
• (S)-2-Propargylglycine

H-Pra-OH

CAS: 23235-01-0

This unusual amino acid is produced by microorganisms, it has been detected in the poisonous mushroom Amanita abrupta. Propargylglycine is a prececursor for tritiated norleucine which may be introduced synthetically into peptides. For a review of the synthetic applications of aliphatic unsaturated α-amino acids see Kaiser et al. Pra has been used in click chemistry. Cyclization of Pra-containing peptides via triazole formation with a lateral azide group proceeds smoothly in the presence of CuBr.

Formula: C₅H₇NO₂

Purity: > 99%

Color and Shape: White Powder

Molecular weight: 113.12

Ref: 01-4010417

4-Pentynoic acid, 2-amino-, (2S)-

CAS: 23235-01-0

Formula: C₅H₇NO₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 113.1146

Ref: IN-DA002MM0

L-C-Propargylglycine

CAS: 23235-01-0

Ref: 7W-GM2502

L-Propargylglycine

CAS: 23235-01-0

L-Propargylglycine

Purity: ≥98%

Molecular weight: 113.11g/mol

Ref: 54-BUP17305

2-Propargyl-L-glycine

CAS: 23235-01-0

2-Propargyl-L-glycine

Formula: C₅H₇NO₂

Purity: 98%

Color and Shape: pale yellow solid

Molecular weight: 113.11g/mol

Ref: 54-OR61064

L-Propargylglycine

CAS: 23235-01-0

L-Propargylglycine ((S)-Propargylglycine) is an inhibitor of the enzyme.

Formula: C₅H₇NO₂

Purity: 99.63% - 99.83%

Color and Shape: White Crystalline Powder

Molecular weight: 113.11

Ref: TM-T20129

L-Propargylglycine

CAS: 23235-01-0

L-Propargylglycine is a novel, synthetic compound that has been shown to inhibit bacterial growth. It is a strong inhibitor of the polymerase chain reaction (PCR) and nuclear DNA replication. L-Propargylglycine has also been shown to inhibit mitochondrial membrane potential and human serum which may lead to its anti-inflammatory properties. L-Propargylglycine has antioxidative properties, antimicrobial peptide activity, and ATP channel inhibition. This drug also has a number of other pharmacological effects including modulation of intestinal inflammation in models of inflammatory bowel disease and improvement of atherosclerotic lesions in animal models.

Formula: C₅H₇NO₂

Purity: (%) Min. 98%

Color and Shape: Powder

Molecular weight: 113.11 g/mol

Ref: 3D-FP40143

(S)-2-Aminopent-4-ynoic acid

CAS: 23235-01-0

Formula: C₅H₇NO₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 113.116

Ref: 10-F208645