CAS 23256-30-6

(±)-Nifurtimox

Description:

(±)-Nifurtimox is a nitroheterocyclic compound primarily used as an antiparasitic medication, particularly in the treatment of Chagas disease caused by the Trypanosoma cruzi parasite. It is characterized by its complex molecular structure, which includes a nitro group that is crucial for its biological activity. The compound exhibits a racemic mixture, meaning it contains equal parts of two enantiomers, which can have different pharmacological effects. Nifurtimox functions by generating reactive oxygen species and disrupting the redox balance within the parasite, ultimately leading to its death. The substance is typically administered orally and is known for its side effects, which can include gastrointestinal disturbances, neurological symptoms, and allergic reactions. Its efficacy and safety profile make it a critical option in regions where Chagas disease is endemic. Additionally, ongoing research is exploring its potential use against other parasitic infections and its mechanisms of action at the molecular level.

Formula: C₁₀H₁₃N₃O₅S

InChI: InChI=1S/C10H13N3O5S/c1-8-7-19(16,17)5-4-12(8)11-6-9-2-3-10(18-9)13(14)15/h2-3,6,8H,4-5,7H2,1H3

InChI key: InChIKey=ARFHIAQFJWUCFH-UHFFFAOYSA-N

SMILES: N(=CC=1OC(N(=O)=O)=CC1)N2C(C)CS(=O)(=O)CC2

Synonyms:

• 1-((5-Nitrofurfurylidene)amino)-2-methyltetrahydro-1,4-thiazine-4,4-dioxide
• 3-Methyl-4-(5'-nitrofurylidene-amino)-tetrahydro-4H-1,4-thiazine-1,1-dioxide
• 3-Methyl-4-(5-nitrofurfurylideneamino)tetrahydro-1,4-thiazine-1,1-dioxide
• 3-methyl-N-[(1E)-(5-nitrofuran-2-yl)methylidene]thiomorpholin-4-amine 1,1-dioxide
• 3-methyl-N-[(5-nitrofuran-2-yl)methylidene]thiomorpholin-4-amine 1,1-dioxide
• 4-((5-Nitrofurfurylidene)amino)-3-methylthiomorpholine 1,1-dioxide
• 4-(5-Nitrofurfurylideneamino)-3-methylthiomorpholine 1,1-dioxide
• 4-Thiomorpholinamine, 3-methyl-N-((5-nitro-2-furanyl)methylene)-, 1,1-dioxide
• Bay 2502
• Bay-A 2502
• Bayer 2502
• Ccris 2201
• Lampit
• Nifurtimox [INN:BAN]
• Nifurtimoxum
• Nifurtimoxum [INN-Latin]
• Tetrahydro-3-methyl-4-((5-nitrofurfurylidene)amino)-2H-1,4-thiazine 1,1-dioxide
• Tetrahydro-3-methyl-4-[(5-nitrofurfurylidene)amino]-4H-1,4-thiazine 1,1-dioxide
• Thiomorpholine, 3-methyl-4-((5-nitrofurfurylidene)amino)-, 1,1-dioxide

4-Thiomorpholinamine, 3-methyl-N-[(5-nitro-2-furanyl)methylene]-, 1,1-dioxide

CAS: 23256-30-6

Formula: C₁₀H₁₃N₃O₅S

Purity: 98%

Color and Shape: Solid

Molecular weight: 287.2923

Ref: IN-DA002MOZ

Nifurtimox

CAS: 23256-30-6

Nifurtimox

Purity: ≥98%

Molecular weight: 287.29g/mol

Ref: 54-BUP15371

Nifurtimox

CAS: 23256-30-6

Formula: C₁₀H₁₃N₃O₅S

Color and Shape: Orange Solid

Molecular weight: 287.29

Ref: 4Z-N-461

Nifurtimox-d4

CAS: 23256-30-6

Formula: C₁₀H₉D₄N₃O₅S

Color and Shape: Orange Solid

Molecular weight: 291.31

Ref: 4Z-N-462

Nifurtimox

CAS: 23256-30-6

Nifurtimox (BAY-A-2502) is an antiprotozoal agent (IC50s = 9.91, 12.28, and 10.44 μM against Taluahuén, LQ, and Brener strains of T.

Formula: C₁₀H₁₃N₃O₅S

Purity: 99.87% - 99.89%

Color and Shape: Solid

Molecular weight: 287.29

Ref: TM-T5325

Nifurtimox

Controlled Product

CAS: 23256-30-6

Formula: C₁₀H₁₃N₃O₅S

Color and Shape: Neat

Molecular weight: 287.29

Ref: TR-N458800