CAS 2326521-71-3

MRTX-849

Description:

MRTX-849, also known by its chemical name as a selective inhibitor of KRAS G12C, is a small molecule designed for targeted cancer therapy. It specifically binds to the KRAS G12C mutant protein, which is commonly associated with various cancers, including non-small cell lung cancer and colorectal cancer. The compound works by locking the KRAS protein in an inactive state, thereby inhibiting its signaling pathways that promote tumor growth and survival. MRTX-849 has shown promise in preclinical and clinical studies, demonstrating efficacy in reducing tumor size and improving patient outcomes. Its pharmacokinetic properties include oral bioavailability, allowing for convenient administration. Additionally, the compound is characterized by its specificity for the G12C mutation, minimizing effects on wild-type KRAS and potentially reducing side effects. As a part of ongoing research, MRTX-849 is being evaluated in combination with other therapies to enhance its effectiveness and overcome resistance mechanisms in cancer treatment.

Synonyms:

• 2-((S)-4-(7-(8-chloronaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile

2-((S)-4-(7-(8-Chloronaphthalen-1-Yl)-2-(((S)-1-Methylpyrrolidin-2-Yl)Methoxy)-5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidin-4-Yl)-1-(2-Fluoroacryloyl)Piperazin-2-Yl)Acetonitrile

CAS: 2326521-71-3

2-((S)-4-(7-(8-Chloronaphthalen-1-Yl)-2-(((S)-1-Methylpyrrolidin-2-Yl)Methoxy)-5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidin-4-Yl)-1-(2-Fluoroacryloyl)Piperazin-2-Yl)Acetonitrile

Purity: 98%

Molecular weight: 604.12g/mol

Ref: 54-PC108396

Adagrasib

CAS: 2326521-71-3

Formula: C₃₂H₃₅ClFN₇O₂

Molecular weight: 604.13

Ref: 4Z-A-415001

Adagrasib

CAS: 2326521-71-3

Adagrasib

Purity: ≥98%

Molecular weight: 604.12g/mol

Ref: 54-BUP16966

Adagrasib

CAS: 2326521-71-3

View and buy Adagrasib (MRTX849) from TargetMol.MRTX849 is a potent, selective and covalent KRASG12C inhibitor with potential antineoplastic activity. Cited in 2 publications.

Formula: C₃₂H₃₅ClFN₇O₂

Purity: 99.10% - 99.9%

Color and Shape: Solid

Molecular weight: 604.12

Ref: TM-T8369

Adagrasib Desmethylene impurity

CAS: 2326521-71-3

Formula: C₃₁H₃₅ClFN₇O₂

Molecular weight: 592.12

Ref: ST-EA-CP-A171012

MRTX849

CAS: 2326521-71-3

MRTX849 is a small molecule inhibitor, which is derived through rational drug design targeting specific oncogenic mutations. It acts as a covalent inhibitor that selectively targets the KRAS G12C mutation, a prevalent alteration in various cancers such as non-small cell lung cancer and colorectal cancer. The mode of action involves binding to the mutated KRAS G12C protein, locking it in an inactive GDP-bound state, thereby inhibiting downstream signaling pathways crucial for tumor cell proliferation and survival.

Formula: C₃₂H₃₅ClFN₇O₂

Purity: Min. 95%

Molecular weight: 604.12 g/mol

Ref: 3D-BM177692