CAS 23277-43-2

Nalbuphine hydrochloride

Description:

Nalbuphine hydrochloride is a synthetic opioid analgesic primarily used for the management of moderate to severe pain. It acts as a mixed agonist-antagonist, meaning it can activate certain opioid receptors while simultaneously blocking others, which can help reduce the risk of addiction and respiratory depression associated with traditional opioids. The substance is typically administered via injection and is known for its relatively low potential for abuse compared to full agonists. Nalbuphine hydrochloride has a rapid onset of action and a duration of effect that can vary based on the route of administration. Its chemical structure includes a phenanthrene core, which is characteristic of many opioid compounds. The hydrochloride salt form enhances its solubility and stability, making it suitable for medical use. Common side effects may include sedation, dizziness, and nausea, similar to other opioids, but its unique receptor activity profile can lead to a different side effect profile. Nalbuphine is also sometimes used in obstetric settings for pain relief during labor.

Formula: C₂₁H₂₇NO₄·ClH

InChI: InChI=1S/C21H27NO4.ClH/c23-14-5-4-13-10-16-21(25)7-6-15(24)19-20(21,17(13)18(14)26-19)8-9-22(16)11-12-2-1-3-12;/h4-5,12,15-16,19,23-25H,1-3,6-11H2;1H/t15-,16+,19-,20-,21+;/m0./s1

InChI key: InChIKey=YZLZPSJXMWGIFH-BCXQGASESA-N

SMILES: O[C@]12[C@@]34C=5C(O[C@]3([C@@H](O)CC1)[H])=C(O)C=CC5C[C@]2(N(CC6CCC6)CC4)[H].Cl

Synonyms:

• (5Alpha,6Alpha)-17-(Cyclobutylmethyl)-4,5-Epoxymorphinan-3,6,14-Triol Hydrochloride
• 17-(Cyclobutylmethyl)-4,5α-epoxymorphinan-3,6α,14-triol hydrochloride
• En 2234A
• Mcv 4385
• Morphinan-3,6,14-triol, 17-(cyclobutylmethyl)-4,5-epoxy-, hydrochloride (1:1), (5α,6α)-
• Morphinan-3,6,14-triol, 17-(cyclobutylmethyl)-4,5-epoxy-, hydrochloride, (5α,6α)-
• Morphinan-3,6α,14-triol, 17-(cyclobutylmethyl)-4,5α-epoxy-, hydrochloride
• N-Cyclobutylmethyl-7,8-dihydro-14-hydroxynormorphine hydrochloride
• Nalbuphine hcl
• Nalufin
• Nih 10274
• Nubain
• Um 686

Nalbuphine Hydrochloride

CAS: 23277-43-2

Color and Shape: Neat

Ref: 61-FOR0341.00

Nalbuphine hydrochloride hydrate

CAS: 23277-43-2

Formula: C₂₁H₂₇NO₄·HCl·xH₂O

Purity: ≥ 98.0%

Color and Shape: White to light yellow powder

Molecular weight: 393.90 (anhydrous)

Ref: 7W-GL4196

Nalbuphine Hydrochloride

Controlled Product

CAS: 23277-43-2

Formula: C₂₁H₂₇NO₄·ClH

Color and Shape: Neat

Molecular weight: 393.90

Ref: 86-MM0341.00

Nalbuphine hydrochloride

Controlled Product

CAS: 23277-43-2

mu-opioid receptor antagonist/ kappa-opioid receptor agonist

Formula: C₂₁H₂₇NO₄·HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 393.9 g/mol

Ref: 3D-BN161328