CAS 23380-54-3

2-Amino-5-(aminosulfonyl)-4-chloro-N-(2-methylphenyl)benzamide

Description:

2-Amino-5-(aminosulfonyl)-4-chloro-N-(2-methylphenyl)benzamide, with the CAS number 23380-54-3, is a chemical compound that features a complex structure characterized by the presence of an amino group, a sulfonamide group, and a chloro substituent on a benzamide backbone. This compound is typically a solid at room temperature and is soluble in polar solvents due to the presence of functional groups that can engage in hydrogen bonding. The sulfonamide group imparts unique properties, including potential biological activity, making it of interest in pharmaceutical research. The chloro substituent can influence the compound's reactivity and stability, while the methylphenyl group may affect its lipophilicity and interaction with biological targets. Overall, this compound's structural features suggest it may have applications in medicinal chemistry, particularly in the development of therapeutic agents. However, specific safety and handling guidelines should be followed, as with all chemical substances, to ensure safe usage in laboratory settings.

Formula: C₁₄H₁₄ClN₃O₃S

InChI: InChI=1/C14H14ClN3O3S/c1-8-4-2-3-5-12(8)18-14(19)9-6-13(22(17,20)21)10(15)7-11(9)16/h2-7H,16H2,1H3,(H,18,19)(H2,17,20,21)

InChI key: InChIKey=YWXVGSRRJLYMHX-UHFFFAOYSA-N

SMILES: C(NC1=C(C)C=CC=C1)(=O)C2=CC(S(N)(=O)=O)=C(Cl)C=C2N

Synonyms:

• 2-Amino-4-chloro-5-sulfamoyl-o-benzotoluidide
• 2-Amino-5-(aminosulfonyl)-4-chloro-N-(2-methylphenyl)benzamide
• 2-amino-4-chloro-N-(2-methylphenyl)-5-sulfamoylbenzamide
• Benzamide, 2-amino-5-(aminosulfonyl)-4-chloro-N-(2-methylphenyl)-
• o-Benzotoluidide, 2-amino-4-chloro-5-sulfamoyl-
• 2-Amino-5-(aminosulphonyl)-4-chloro-N-(o-tolyl)benzamide
• 2-Amino-4-chloro-5-sulfamoyl-o-benzotoluidid
• Metolazone EP Impurity E
• 2-amino-5-(aminosulfonyl)-4-chloro-N-(o-tolyl)benzamide
• Metolazone EP Impurity E (Metolazone Benzamide Analog)
• Metolazone Impurity B
• Metolazone Impurity 5 （Metolazone EP Impurity E）
• Einecs 245-620-4

Metolazone EP Impurity E

CAS: 23380-54-3

Formula: C₁₄H₁₄ClN₃O₃S

Color and Shape: Off-White Solid

Molecular weight: 339.79

Ref: 4Z-M-744

2-Amino-4-chloro-5-sulfamoyl-o-benzotoluidide

Controlled Product

CAS: 23380-54-3

Applications 2-Amino-4-chloro-5-sulfamoyl-o-benzotoluidide is an intermediate in the synthesis of Metolazone (M338750); a diuretic and antihypertensive agent.
References Curry, C.L., et al.: Clin. Ther., 9, 47 (1986); Kiyingi, A., et al.: Lancet, 335, 29 (1990); Chen, G., et al.: Shenyang Yaoke Daxue Xuebao, 21, 109 (2004)

Formula: C₁₄H₁₄ClN₃O₃S

Color and Shape: Neat

Molecular weight: 339.8

Ref: TR-A604420

Metolazone EP Impurity E

CAS: 23380-54-3

Formula: C₁₄H₁₄ClN₃O₃S

Molecular weight: 339.79

Ref: ST-EA-CP-M16005