CAS 2353409-45-5

BCN-PEG3-VC-PFP ester

Description:

BCN-PEG3-VC-PFP ester is a chemical compound characterized by its unique structure that combines a bicyclo[6.1.0]nonyne (BCN) moiety with a polyethylene glycol (PEG) segment and a vinyl carbamate (VC) functional group, along with a pentafluorophenyl (PFP) ester. This compound is notable for its biocompatibility and solubility in aqueous environments, making it suitable for various biomedical applications, particularly in drug delivery and bioconjugation. The PEG segment enhances its hydrophilicity and reduces protein adsorption, which is advantageous for in vivo applications. The BCN moiety allows for efficient click chemistry reactions, particularly with azides, facilitating the formation of stable covalent bonds. The presence of the PFP group provides a reactive site for further functionalization or conjugation with other biomolecules. Overall, BCN-PEG3-VC-PFP ester is a versatile compound that combines the benefits of bioorthogonal chemistry with the favorable properties of PEG, making it a valuable tool in the fields of chemical biology and materials science.

Formula: C₃₇H₅₀F₅N₅O₁₀

Synonyms:

• BCN-PEG3-VC-PFP ester

BCN-PEG3-VC-PFP ester

CAS: 2353409-45-5

BCN-PEG3-VC-PFP ester is a three-unit PEG ADC linker that can be cleaved, and it is commonly employed in the synthesis of antibody-drug conjugates (ADCs) [1].

Formula: C₃₇H₅₀F₅N₅O₁₀

Purity: 98%

Color and Shape: Solid

Molecular weight: 819.81

Ref: TM-T17532

BCN-PEG3-vc-pfp ester

CAS: 2353409-45-5

BCN-PEG3-vc-pfp ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. BCN-PEG3-vc-pfp ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Formula: C₃₇H₅₀F₅N₅O₁₀

Purity: Min. 95%

Molecular weight: 819.8 g/mol

Ref: 3D-DUD40945